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Verfasst von:Fairless, Richard [VerfasserIn]   i
 Williams-Fairless, Sarah K. [VerfasserIn]   i
 Stojic, Aleksandar [VerfasserIn]   i
 Diem, Ricarda [VerfasserIn]   i
Titel:Preclinical retinal neurodegeneration in a model of multiple wclerosis
Verf.angabe:Richard Fairless, Sarah K. Williams, Dorit B. Hoffmann, Aleksandar Stojic, Sonja Hochmeister, Frank Schmitz, Maria K. Storch, and Ricarda Diem
E-Jahr:2012
Jahr:18 April 2012
Umfang:13 S.
Illustrationen:Illustrationen
Fussnoten:Gesehen am 14.11.2018
Titel Quelle:Enthalten in: The journal of neuroscience
Ort Quelle:Washington, DC : Soc., 1981
Jahr Quelle:2012
Band/Heft Quelle:32(2012), 16, Seite 5585-5597
ISSN Quelle:1529-2401
Abstract:Neurodegeneration plays a major role in multiple sclerosis (MS), in which it is thought to be the main determinant of permanent disability. However, the relationship between the immune response and the onset of neurodegeneration is still a matter of debate. Moreover, recent findings in MS patients raised the question of whether primary neurodegenerative changes can occur in the retina independent of optic nerve inflammation. Using a rat model of MS that frequently leads to optic neuritis, we have investigated the interconnection between neurodegenerative and inflammatory changes in the retina and the optic nerves with special focus on preclinical disease stages. We report that, before manifestation of optic neuritis, characterized by inflammatory infiltration and demyelination of the optic nerve, degeneration of retinal ganglion cell bodies had already begun and ultrastructural signs of axon degeneration could be detected. In addition, we observed an early activation of resident microglia in the retina. In the optic nerve, the highest density of activated microglia was found within the optic nerve head. In parallel, localized breakdown in the integrity of the blood-retinal barrier and aberrations in the organization of the blood-brain barrier marker aquaporin-4 in the optic nerves were observed during the preclinical phase, before onset of optic neuritis. From these findings, we conclude that early and subtle inflammatory changes in the retina and/or the optic nerve head reminiscent of those suggested for preclinical MS lesions may initiate the process of neurodegeneration in the retina before major histopathological signs of MS become manifest.
DOI:doi:10.1523/JNEUROSCI.5705-11.2012
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: http://dx.doi.org/10.1523/JNEUROSCI.5705-11.2012
 Volltext: http://www.jneurosci.org/content/32/16/5585
 DOI: https://doi.org/10.1523/JNEUROSCI.5705-11.2012
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1583722807
Verknüpfungen:→ Zeitschrift

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