| |  Online-Ressource |
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| Verfasst von: | Felcht, Moritz [VerfasserIn]  |
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| | Heck, Markus [VerfasserIn] |
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| | Weiß, Christel [VerfasserIn] |
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| | Nicolay, Jan Peter [VerfasserIn] |
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| | Booken, Nina [VerfasserIn] |
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| | Goerdt, Sergij [VerfasserIn] |
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| | Klemke, Claus-Detlev [VerfasserIn] |
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| Titel: | Expression of the T-cell regulatory marker FOXP3 in primary cutaneous large B-cell lymphoma tumour cells |
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| Verf.angabe: | M. Felcht, M. Heck, C. Weiss, J.C. Becker, E. Dippel, C.S.L. Müller, D. Nashan, M.M. Sachse, J.P. Nicolay, N. Booken, S. Goerdt, and C.-D. Klemke |
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| E-Jahr: | 2012 |
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| Jahr: | 18 April 2012 |
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| Umfang: | 11 S. |
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| Fussnoten: | Gesehen am 15.11.2018 |
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| Titel Quelle: | Enthalten in: British journal of dermatology |
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| Ort Quelle: | Oxford : Oxford University Press, 1892 |
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| Jahr Quelle: | 2012 |
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| Band/Heft Quelle: | 167(2012), 2, Seite 348-358 |
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| ISSN Quelle: | 1365-2133 |
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| Abstract: | BACKGROUND: Primary cutaneous B-cell lymphomas (PCBCL) are subdivided into the aggressive form, primary cutaneous diffuse large B-cell lymphoma, leg type (PCLBCL, LT) and two subtypes of indolent behaviour (primary cutaneous follicle centre lymphoma and primary cutaneous marginal zone B-cell lymphoma). The difference in clinical behaviour can be explained by the tumour cell itself, or the lymphoma microenvironment including the antitumour immune response. OBJECTIVES: To investigate the presence of regulatory T cells (Treg), CD4+CD25+FOXP3+, in the microenvironment of PCBCL in correlation with clinical outcome. METHODS: Tumour specimens of 55 consecutive cases of PCBCL were blinded and analysed for FOXP3, CD4 and CD25 expression by immunohistochemistry. Confocal images were taken with a Leica SP5. Statistical analyses were performed to determine significance. The test was considered significant when P<0.05. RESULTS: The CD4 and FOXP3 expression as well as the CD4/FOXP3 ratio were significantly increased in PCBCL of indolent behaviour in contrast to PCLBCL, LT (P=0.0002 for CD4, P<0.0001 for FOXP3 and P=0.0345 for FOXP3/CD4 ratio). CD25 expression did not differ in the three groups (P=0.9414). Within the group of patients with PCLBCL, LT we identified a subgroup with FOXP3+ tumour cells as demonstrated by CD20/FOXP3 double stainings. Patients with FOXP3+ PCLBCL, LT tumour cells showed a better prognosis on Kaplan-Meier analysis. CONCLUSION: High numbers of Treg in the lymphoma microenvironment correlate with a better prognosis in PCBCL. In PCLBCL, LT the presence of FOXP3+ tumour cells is beneficial for prognosis suggesting that FOXP3 expression of PCLBCL, LT tumour cells might serve as a tumour suppressor. |
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| DOI: | doi:10.1111/j.1365-2133.2012.10987.x |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://dx.doi.org/10.1111/j.1365-2133.2012.10987.x |
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| | DOI: https://doi.org/10.1111/j.1365-2133.2012.10987.x |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Aged |
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| | Aged, 80 and over |
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| | Biomarkers, Tumor |
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| | CD4 Antigens |
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| | Female |
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| | Forkhead Transcription Factors |
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| | Humans |
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| | Interleukin-2 Receptor alpha Subunit |
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| | Kaplan-Meier Estimate |
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| | Lymphoma, B-Cell, Marginal Zone |
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| | Lymphoma, Large B-Cell, Diffuse |
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| | Male |
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| | Middle Aged |
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| | Skin Neoplasms |
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| | Tumor Microenvironment |
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| K10plus-PPN: | 1583737812 |
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| Verknüpfungen: | → Zeitschrift |
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Expression of the T-cell regulatory marker FOXP3 in primary cutaneous large B-cell lymphoma tumour cells / Felcht, Moritz [VerfasserIn]; 18 April 2012 (Online-Ressource)
