Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Schildhorn, Carolin [VerfasserIn]   i
 Westhoff, Jens [VerfasserIn]   i
 Gretz, Norbert [VerfasserIn]   i
 Kränzlin, Bettina [VerfasserIn]   i
Titel:Renal phenotype of young and old telomerase-deficient mice
Verf.angabe:Carolin Schildhorn, Christoph Jacobi, Andrea Weißbrodt, Christine Hermstedt, Jens Hendrik Westhoff, Meike Hömme, Raj Bhayadia, Norbert Gretz, Christine Susanne Falk, Roland Schmitt, Verena Bröcker, Bettina Kränzlin, Anette Melk
E-Jahr:2015
Jahr:September 2015
Umfang:9 S.
Fussnoten:Gesehen am 19.11.2018 ; Available online 12 August 2015
Titel Quelle:Enthalten in: Mechanisms of ageing and development
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1972
Jahr Quelle:2015
Band/Heft Quelle:150(2015), Seite 65-73
ISSN Quelle:1872-6216
Abstract:Telomere shortening in the kidney explains the impaired regenerative capacity, but may not drive the ageing phenotype itself. We investigated kidneys from young and old Terc+/+ and Terc−/− mice of early (G1) and late (G4, G5) generations. Functional parameters declined and age-related morphological changes increased in late generation Terc−/− mice and with further age. Podocyte loss was only seen in old G4 Terc−/−. Whereas p21CIP1/WAF1 was highest in old G1 and G4 Terc−/−, telomere shortening and p16INK4a expression, also significantly associated with later generation young Terc−/−, were not further induced in old Terc−/− mice. Both, young and old late generation Terc−/−, showed increased pro-inflammatory cytokine levels. Young late generation Terc−/− animals show mild functional and histological abnormalities, the presence of cellular senescence explains their kidneys’ limited regenerative capacity. While these aspects resemble the situation seen in aged human kidneys, the lack of telomere shortening and p16INK4a induction in older Terc−/− animals differs from observations in old human kidneys and may result from clearance of senescent cells. This animal model is well suited to investigate the mechanisms of impaired renal regeneration in aged human kidney, but may not fully explain the natural course of the human renal ageing phenotype.
DOI:doi:10.1016/j.mad.2015.08.004
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1016/j.mad.2015.08.004
 Volltext: http://www.sciencedirect.com/science/article/pii/S0047637415300087
 DOI: https://doi.org/10.1016/j.mad.2015.08.004
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Kidney
 Knockout-mouse
 Senescence
 Telomerase
 Telomere
K10plus-PPN:1583851585
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68329847   QR-Code
zum Seitenanfang