Galectin-3 binding protein plasma levels are associated with long-term mortality in coronary artery disease independent of plaque morphology

• Verfasst von: Gleißner, Christian A. [VerfasserIn]
• Verfasst von: Erbel, Christian [VerfasserIn]
• Verfasst von: Linden, Fabian [VerfasserIn]
• Verfasst von: Domschke, Gabriele [VerfasserIn]
• Verfasst von: Akhavanpoor, Mohammadreza [VerfasserIn]
• Verfasst von: Dösch, Andreas [VerfasserIn]
• Verfasst von: Buß, Sebastian Johannes [VerfasserIn]
• Verfasst von: Giannitsis, Evangelos [VerfasserIn]
• Verfasst von: Katus, Hugo [VerfasserIn]
• Verfasst von: Korosoglou, Grigorios [VerfasserIn]
• Titel: Galectin-3 binding protein plasma levels are associated with long-term mortality in coronary artery disease independent of plaque morphology
• Verf.angabe: Christian A. Gleissner, Christian Erbel, Fabian Linden, Gabriele Domschke, Mohammadreza Akhavanpoor, Andreas O. Doesch, Sebastian J. Buss, Evangelos Giannitsis, Hugo A. Katus, Grigorios Korosoglou
• E-Jahr: 2016
• Jahr: August 2016
• Umfang: 7 S.
• Fussnoten: Gesehen am 20.11.2018
• Titel Quelle: Enthalten in: Atherosclerosis
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1970
• Jahr Quelle: 2016
• Band/Heft Quelle: 251(2016), Seite 94-100
• ISSN Quelle: 1879-1484
• DOI: doi:10.1016/j.atherosclerosis.2016.06.002
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Biomarker
• Sach-SW: CCTA
• Sach-SW: Coronary artery disease
• Sach-SW: Galectin-3 binding protein
• Sach-SW: Outcome
• Sach-SW: Plaque morphology
• K10plus-PPN: 1583868291

Abstract

Background and aims Galectin-3 binding protein (Gal-3BP) is a secreted protein associated with inflammation and carotid atherosclerosis. We hypothesized that high Gal-3BP levels may indicate unfavorable plaque morphology and outcome in coronary artery disease (CAD). Methods Gal-3BP plasma levels were measured by ELISA in 233 patients (63 ± 10 years, 50.2% male) undergoing computed coronary angiography tomography (CCTA). Results In 149 patients, CCTA confirmed CAD (stenosis grade >20%). Mean Gal-3BP plasma levels were 5.9 ± 2.7 μg/mL and did not differ between patients with or without CAD. Over a follow-up time of up to 4.4 years (median 2.5 years), there were 17 cases of revascularization, five cases of myocardial infarction, and five deaths (four non-cardiac, one fatal myocardial infarction). Kaplan-Meier analysis revealed that high Gal-3BP levels were significantly associated with long-term mortality (p < 0.001). Cox proportional hazards regression analysis showed that this association was independent of cardiovascular risk factors (HR 1.238, 95%-CI 1.012-1.514, p = 0.038). After adjustment for troponin T and C-reactive protein (hs-CRP) levels, significance was lost (p = 0.123). Further analysis revealed that Gal-3BP levels were significantly related to body mass index and hs-CRP levels indicating an association with metabolic and inflammatory distress. There was no correlation between Gal-3BP and calcium score, plaque volume, or vascular remodeling. Conclusions While high Gal-3BP plasma levels are associated with long-term mortality, we could not confirm it as a marker of cardiac mortality or unstable plaque morphology.