Die therapeutischen Effekte endothelialer Progenitorzellen beim LPS-induzierten ARDS

• Verfasst von: Rafat, Neysan [VerfasserIn]
• Verfasst von: Dacho, Christine [VerfasserIn]
• Verfasst von: Krebs, Jörg [VerfasserIn]
• Verfasst von: Tsagogiorgas, Charalambos [VerfasserIn]
• Verfasst von: Yard, Benito A. [VerfasserIn]
• Verfasst von: Beck, Grietje [VerfasserIn]
• Titel: Die therapeutischen Effekte endothelialer Progenitorzellen beim LPS-induzierten ARDS
• Paralleltitel: Therapeutic effects of endothelial progenitor cells in LPS-induced ARDS
• Verf.angabe: N. Rafat, C. Dacho, G. Kowanetz, J. Krebs, C. Tsagogiorgas, V. Ghezel-Ahmadi, B. Yard, G. Beck
• E-Jahr: 2012
• Jahr: April 2012
• Umfang: 13 S.
• Fussnoten: Gesehen am 23.11.2018
• Titel Quelle: Enthalten in: Anästhesiologie & Intensivmedizin
• Ort Quelle: Ebelsbach : Aktiv Dr. und Verl., 1978
• Jahr Quelle: 2012
• Band/Heft Quelle: 53(2012), 4, Seite 196-208
• ISSN Quelle: 1439-0256
• Datenträger: Online-Ressource
• Sprache: ger
• K10plus-PPN: 1584356596

Abstract

Background: Endotoxin-induced ARDS is characterized by diffuse dysfunction of the microvasculature including increased permeability with edema formation and apoptosis or necrosis of endothelial and epithelial cells. Concomitantly, an increased concentration of circulating endothelial progenitor cells (EPC) was found in septic patients, of which more than half have pulmonary involvement. The number of circulating EPC correlated inversely to disease severity and mortality. Since these EPC were found homing to damaged lung tissue, a reparative process seems to be initiated right after the initiation of vessel damage or degeneration. In the present study we investigated the potential of EPC as a treatment strategy in ARDS.