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Status: Bibliographieeintrag

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Verfasst von:Radu, Christian Andreas [VerfasserIn]   i
 Horn, Dominik [VerfasserIn]   i
 Kiefer, Jurij [VerfasserIn]   i
 Gebhard, Martha-Maria [VerfasserIn]   i
 Ryssel, Henning [VerfasserIn]   i
 Köllensperger, Eva [VerfasserIn]   i
 Germann, Günter [VerfasserIn]   i
 Kremer, Thomas [VerfasserIn]   i
Titel:Donor-derived transplant acceptance-inducing cells in composite tissue allotransplantation
Verf.angabe:C.A. Radu, D. Horn, J. Kiefer, M. Rebel, M.M. Gebhard, H. Ryssel, E. Köllensperger, F. Fändrich, G. Germann, T. Kremer
E-Jahr:2012
Jahr:December 2012
Umfang:8 S.
Fussnoten:Gesehen am 26.11.2018
Titel Quelle:Enthalten in: Journal of plastic, reconstructive & aesthetic surgery
Ort Quelle:Amsterdam [u.a.] : Elsevier, 2006
Jahr Quelle:2012
Band/Heft Quelle:65(2012), 12, Seite 1684-1691
ISSN Quelle:1878-0539
Abstract:Background: Composite tissue allotransplantation (CTA) is a newly emerging field of transplantation. Immunological research in CTA has been intensified due to the recent clinical success of hand and face transplantation. Establishing immunological tolerance by adoptive transfer of ex vivo cultured tolerance-inducing cell types is of growing interest. Transplant acceptance-inducing cells (TAICs) are a type of deactivated immunoregulatory macrophages. Methods: A total of 36 allogeneic hind limb transplantations in the rat were performed in six groups. Group A (Lewis (LW) → Brown-Norway (BN)) received Lewis-donor-derived TAICs locally (i.m.). Group B (LW → BN) received Lewis-donor-derived TAICs systemically (i.v.) and group C (Sprague Dawley (Sp-D) → BN) served as a control group receiving Lewis-donor-derived TAICs systemically (i.v.). Groups D (LW → BN), E (LW → BN), and F (BN → BN) also served as control groups with group D receiving no immunosuppression, group E receiving FK506 and prednisolone and group F receiving no immunosuppression with isograft transplantations (BN → BN). The timing of rejection was assessed by clinical observation and histological findings. Results: Rejection of the allogeneic hind limb occurred on average 7.7 days after transplantation in group A and 7.4 days in group B. Rejection was significantly delayed (Log-rank test, p < 0.01) compared to groups C and D, where rejection of the allogeneic hind limb occurred on average 5.8 days and 5.6 days after transplantation. No rejection was seen in groups E and F. Conclusion: For the first time, TAICs have been applied in a CTA model and demonstrated a significant immunosuppressive effect. Even though the immunomodulatory effect is relatively modest, the results of this study justify subsequent research on TAIC therapy to improve experimental and clinical outcome after CTA.
DOI:doi:10.1016/j.bjps.2012.07.003
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1016/j.bjps.2012.07.003
 Volltext: http://www.sciencedirect.com/science/article/pii/S1748681512003889
 DOI: https://doi.org/10.1016/j.bjps.2012.07.003
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Cell based therapy
 Composite tissue allotransplantation
 CTA
 Hind limb transplantation
 Macrophage
 Prope tolerance
 TAIC
K10plus-PPN:1584430052
Verknüpfungen:→ Zeitschrift

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