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Verfasst von:Etzl, Ronny [VerfasserIn]   i
 Pöschl, Johannes [VerfasserIn]   i
 Rotzoll, Daisy E. [VerfasserIn]   i
Titel:Oxidative stress stimulates α-tocopherol transfer protein in human trophoblast tumor cells BeWo
Verf.angabe:Ronny P. Etzl, Thomas Vrekoussis, Christina Kuhn, Sandra Schulze, Johannes M. Pöschl, Antonis Makrigiannakis, Udo Jeschke and Daisy E. Rotzoll
Umfang:6 S.
Fussnoten:Gesehen am 26.11.2018
Titel Quelle:Enthalten in: Journal of perinatal medicine
Jahr Quelle:2012
Band/Heft Quelle:40(2012), 4, S. 373-378
ISSN Quelle:1619-3997
Abstract:α-Tocopherol transfer protein (α-TTP) has been identified as the major intracellular transport protein for the antioxidant vitamin E (α-tocopherol). Expression of α-TTP on the reproductive system has been described both in mouse uterus and lately in the human placenta. The aim of this study was to clarify if placental expression of α-TTP can be modified by substances causing oxidative reactions. The human choriocarcinoma cell line BeWo was, therefore, treated with two known pro-oxidants. α-TTP expression was determined with immunocytochemistry and evaluated by applying a semiquantitative score. The presence of pro-oxidants in BeWo cells induced α-TTP expression. We thus hypothesize that stimulation of α-TTP expression by oxidative stress, as this was induced by pro-oxidants, could be part of an antioxidant process occurring in the placenta in the aim of enhancing the supply of α-tocopherol. This process could occur both in normal pregnancies, as well as in pregnancy disorders presented with intensified oxidative stress. In that view, this model is proposed for further oxidative stress studies on trophoblast and placenta, on the grounds of clarifying the role of α-tocopherol in pregnancy physiology and pathophysiology.
DOI:doi:10.1515/jpm-2011-0307
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Verlag: http://dx.doi.org/10.1515/jpm-2011-0307
 Verlag: https://www.degruyter.com/view/j/jpme.2012.40.issue-4/jpm-2011-0307/jpm-2011-0307.xml
 DOI: https://doi.org/10.1515/jpm-2011-0307
Sprache:eng
K10plus-PPN:1584441305
Verknüpfungen:→ Zeitschrift

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