New neurons in the adult striatum

• Verfasst von: Inta, Dragos [VerfasserIn]
• Verfasst von: Cameron, Heather A. [VerfasserIn]
• Verfasst von: Gass, Peter [VerfasserIn]
• Titel: New neurons in the adult striatum
• Titelzusatz: from rodents to humans
• Verf.angabe: Dragos Inta, Heather A. Cameron, and Peter Gass
• E-Jahr: 2015
• Jahr: September 2015
• Umfang: 7 S.
• Fussnoten: Gesehen am 26.11.2018 ; Available online 20 August 2015
• Titel Quelle: Enthalten in: Trends in neurosciences
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1978
• Jahr Quelle: 2015
• Band/Heft Quelle: 38(2015), 9, Seite 517-523
• ISSN Quelle: 1878-108X
• DOI: doi:10.1016/j.tins.2015.07.005
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: striatum
• Sach-SW: adult neurogenesis
• Sach-SW: GABAergic interneurons
• Sach-SW: humans
• Sach-SW: subventricular zone
• K10plus-PPN: 1584444843

Abstract

Most neurons are generated during development and are not replaced during adulthood, even if they are lost to injury or disease. However, it is firmly established that new neurons are generated in the dentate gyrus of the hippocampus of almost all adult mammals, including humans. Nevertheless, many questions remain regarding adult neurogenesis in other brain regions and particularly in humans, where standard birth-dating methods are not generally feasible. Exciting recent evidence indicates that calretinin-expressing interneurons are added to the adult human striatum at a substantial rate. The role of new neurons is unknown, but studies in rodents will be able to further elucidate their identity and origin and then we may begin to understand their regulation and function.