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Verfasst von:Werk, Tobias [VerfasserIn]   i
 Hafner, Mathias [VerfasserIn]   i
Titel:A method to determine the kinetics of solute mixing in liquid/liquid formulation dual-chamber syringes
Verf.angabe:Tobias Werk, Hanns-Christian Mahler, Imke Sonja Ludwig, Joerg Luemkemann, Joerg Huwyler, and Mathias Hafner
Jahr:2017
Jahr des Originals:2016
Umfang:9 S.
Fussnoten:Published online: August 11, 2016 ; Gesehen am 26.11.2018
Titel Quelle:Enthalten in: Parenteral Drug AssociationPDA Journal of pharmaceutical science and technology
Ort Quelle:Bethesda, Md. : PDA, 1998
Jahr Quelle:2017
Band/Heft Quelle:71(2017), 1, Seite 2-10
ISSN Quelle:1948-2124
Abstract:Dual-chamber syringes were originally designed to separate a solid substance and its diluent. However, they can also be used to separate liquid formulations of two individual drug products, which cannot be co-formulated due to technical or regulatory issues. A liquid/liquid dual-chamber syringe can be designed to achieve homogenization and mixing of both solutions prior to administration, or it can be used to sequentially inject both solutions. While sequential injection can be easily achieved by a dual-chamber syringe with a bypass located at the needle end of the syringe barrel, mixing of the two fluids may provide more challenges. Within this study, the mixing behavior of surrogate solutions in different dual-chamber syringes is assessed. Furthermore, the influence of parameters such as injection angle, injection speed, agitation, and sample viscosity were studied. It was noted that mixing was poor for the commercial dual-chamber syringes (with a bypass designed as a longitudinal ridge) when the two liquids significantly differ in their physical properties (viscosity, density). However, an optimized dual-chamber syringe design with multiple bypass channels resulted in improved mixing of liquids. LAY ABSTRACT: Dual-chamber syringes were originally designed to separate a solid substance and its diluent. However, they can also be used to separate liquid formulations of two individual drug products. A liquid/liquid dual-chamber syringe can be designed to achieve homogenization and mixing of both solutions prior to administration, or it can be used to sequentially inject both solutions. While sequential injection can be easily achieved by a dual-chamber syringe with a bypass located at the needle end of the syringe barrel, mixing of the two fluids may provide more challenges. Within this study, the mixing behavior of surrogate solutions in different dual-chamber syringes is assessed. Furthermore, the influence of parameters such as injection angle, injection speed, agitation, and sample viscosity were studied. It was noted that mixing was poor for the commercially available dual-chamber syringes when the two liquids significantly differ in viscosity and density. However, an optimized dual-chamber syringe design resulted in improved mixing of liquids.
DOI:doi:10.5731/pdajpst.2016.006601
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.5731/pdajpst.2016.006601
 Volltext: http://journal.pda.org/content/71/1/2
 DOI: https://doi.org/10.5731/pdajpst.2016.006601
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1584446749
Verknüpfungen:→ Zeitschrift

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