| |  Online-Ressource |
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| Verfasst von: | Meier, Sandra Melanie [VerfasserIn]  |
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| | Demirakça, Traute [VerfasserIn] |
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| | Brusniak, Wencke [VerfasserIn] |
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| | Wolf, Isabella [VerfasserIn] |
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| | Liebsch, Kristin [VerfasserIn] |
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| | Tunç-Skarka, Nuran [VerfasserIn] |
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| | Nieratschker, Vanessa [VerfasserIn] |
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| | Witt, Stephanie [VerfasserIn] |
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| | Matthäus, Franziska [VerfasserIn] |
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| | Ende, Gabriele [VerfasserIn] |
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| | Flor, Herta [VerfasserIn] |
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| | Rietschel, Marcella [VerfasserIn] |
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| | Diener, Carsten [VerfasserIn] |
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| | Schulze, Thomas Gerd [VerfasserIn] |
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| Titel: | SCN1A affects brain structure and the neural activity of the aging brain |
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| Verf.angabe: | Sandra Meier, Traute Demirakca, Wencke Brusniak, Isabella Wolf, Kristin Liebsch, Nuran Tunc-Skarka, Vanessa Nieratschker, Stephanie H. Witt, Franziska Matthäus, Gabriele Ende, Herta Flor, Marcella Rietschel, Carsten Diener, and Thomas G. Schulze |
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| E-Jahr: | 2012 |
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| Jahr: | 23 April 2012 |
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| Umfang: | 7 S. |
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| Fussnoten: | Gesehen am 23.11.2018 |
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| Titel Quelle: | Enthalten in: Biological psychiatry |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1985 |
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| Jahr Quelle: | 2012 |
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| Band/Heft Quelle: | 72(2012), 8, Seite 677-683 |
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| ISSN Quelle: | 1873-2402 |
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| Abstract: | Background: The aging of the human brain is accompanied by changes in cortical structure as well as functional activity and variable degrees of cognitive decline. One-third of the observable inter-individual differences in cognitive decline are thought to be heritable. SCN1A encodes the sodium channel α subunit and is considered to be a susceptibility gene for several neurological disorders with prominent cognitive deficits. In a recent genome-wide association study the C allele of the SCN1A variant rs10930201 was observed to be significantly associated with poor short-term memory performance. rs10930201 was further observed to be related to differences in neural activity during a working memory task. Methods: The aim of the present study was to explore whether SCN1A modifies the vulnerability to aging processes of the human brain. Therefore we assessed the interacting effects of the SCN1A vulnerability allele rs10930201 and age in terms of brain activity and brain morphology in 62 healthy volunteers between 21 and 82 years of age. Results: In C allele carriers, activity in the right inferior frontal cortex and the posterior cingulate cortex increased with age. Moreover, exploratory analysis revealed regional effects of rs10930201 on brain structure, indicating reduced gray matter densities in the frontal and insular regions in the C allele carriers. Conclusions: Collectively, the present results suggest that the SCN1A polymorphism has modulatory effects on brain morphology and vulnerability to age-related alterations in brain activity of cortical regions that subserve working memory. |
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| DOI: | doi:10.1016/j.biopsych.2012.03.017 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://dx.doi.org/10.1016/j.biopsych.2012.03.017 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S0006322312002661 |
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| | DOI: https://doi.org/10.1016/j.biopsych.2012.03.017 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Aging |
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| | cognition |
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| | frontal cortex |
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| | posterior cingulate cortex |
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| | working memory |
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| K10plus-PPN: | 1584480254 |
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| Verknüpfungen: | → Zeitschrift |
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SCN1A affects brain structure and the neural activity of the aging brain / Meier, Sandra Melanie [VerfasserIn]; 23 April 2012 (Online-Ressource)
