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Verfasst von:Radbruch, Alexander [VerfasserIn]   i
 Haase, Robert [VerfasserIn]   i
 Weberling, Lukas D. [VerfasserIn]   i
 Vollmuth, Philipp [VerfasserIn]   i
 Wick, Wolfgang [VerfasserIn]   i
 Bendszus, Martin [VerfasserIn]   i
Titel:No signal intensity increase in the dentate nucleus on unenhanced T1-weighted MR images after more than 20 serial injections of macrocyclic gadolinium-based contrast agents
Verf.angabe:Alexander Radbruch, Robert Haase, Pascal J. Kieslich, Lukas D. Weberling, Philipp Kickingereder, Wolfgang Wick, Heinz-Peter Schlemmer, Martin Bendszus
Jahr:2017
Umfang:9 S.
Fussnoten:Published online: Dec 7 2016 ; Gesehen am 27.11.2018
Titel Quelle:Enthalten in: Radiology
Ort Quelle:Oak Brook, Ill. : Soc., 1923
Jahr Quelle:2017
Band/Heft Quelle:282(2017), 3, Seite 699-707
ISSN Quelle:1527-1315
Abstract:PurposeTo determine the effect of more than 20 serial injections of macrocyclic gadolinium-based contrast agents (GBCAs) on the signal intensity (SI) of the dentate nucleus (DN) on unenhanced T1-weighted magnetic resonance (MR) images.Materials and MethodsIn this retrospective, institutional review board-approved study, 33 patients who underwent at least 20 consecutive MR imaging examinations (plus an additional MR imaging for reference) with the exclusive use of macrocyclic GBCAs gadoterate meglumine and gadobutrol were analyzed. SI ratio differences were calculated for DN-to-pons and DN-to-middle cerebellar peduncle (MCP) ratios by subtracting the SI ratio at the first MR imaging examination from the SI ratio at the last MR imaging examination. One-sample t tests were used to examine if the SI ratio differences differed from 0, and Bayes factors were calculated to quantify the strength of evidence for each test.ResultsPatients underwent a mean of 23.03 ± (standard deviation) 4.20 GBCA administrations (mean accumulated dose, 491.21 mL ± 87.04 of a 0.5 M GBCA solution) with an average of 12.09 weeks ± 2.16 between every administration. Both ratio differences did not differ significantly from 0 (DN-to-pons ratio: −0.0032 ± 0.0154, P = .248; DN-to-MCP ratio: −0.0011 ± 0.0093, P = .521), and one-sided Bayes factors provided substantial to strong evidence against an SI ratio increase (Bayes factor for DN-to-pons ratio = 0.09 and that for DN-to-MCP ratio = 0.12).ConclusionThe study indicates that 20 or more serial injections of macrocyclic GBCAs administered with on average 3 months between each injection are not associated with an SI increase in the DN.© RSNA, 2016
DOI:doi:10.1148/radiol.2016162241
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: http://dx.doi.org/10.1148/radiol.2016162241
 Volltext: https://pubs.rsna.org/doi/10.1148/radiol.2016162241
 DOI: https://doi.org/10.1148/radiol.2016162241
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1584517506
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