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Verfasst von:Kudryashev, Mikhail [VerfasserIn]   i
 Münter, Sylvia [VerfasserIn]   i
 Lemgruber, Leandro [VerfasserIn]   i
 Cyrklaff, Marek [VerfasserIn]   i
 Frischknecht, Friedrich [VerfasserIn]   i
Titel:Structural basis for chirality and directional motility of Plasmodium sporozoites
Verf.angabe:Mikhail Kudryashev, Sylvia Münter, Leandro Lemgruber, Georgina Montagna, Henning Stahlberg, Kai Matuschewski, Markus Meissner, Marek Cyrklaff and Friedrich Frischknecht
E-Jahr:2012
Jahr:November 2012
Umfang:12 S.
Fussnoten:Gesehen am 28.11.2018
Titel Quelle:Enthalten in: Cellular microbiology
Ort Quelle:Oxford [u.a.] : Wiley-Blackwell, 1999
Jahr Quelle:2012
Band/Heft Quelle:14(2012), 11, Seite 1757-1768
ISSN Quelle:1462-5822
Abstract:Plasmodium sporozoites can move at high speed for several tens of minutes, which is essential for the initial stage of a malaria infection. The crescent-shaped sporozoites move on 2D substrates preferably in the same direction on circular paths giving raise to helical paths in 3D matrices. Here we determined the structural basis that underlies this type of movement. Immature, non-motile sporozoites were found to lack the subpellicular network required for obtaining the crescent parasite shape. In vitro, parasites moving in the favoured direction move faster and more persistent than the few parasites that move in the opposite direction. Photobleaching experiments showed that sporozoites flip their ventral side up when switching the direction of migration. Cryo-electron tomography revealed a polarized arrangement of microtubules and polar rings towards the substrate in Plasmodium sporozoites, but not in the related parasite Toxoplasma gondii. As aconsequence, secretory vesicles, which release proteins involved in adhesion, migration and invasion at the front end of the parasite, are delivered towards the substrate. The resulting chiral structure of the parasite appears to determine the unique directionality of movement and could explain how the sporozoite achieves rapid and sustained directional motility in the absence of external stimuli.
DOI:doi:10.1111/j.1462-5822.2012.01836.x
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: http://dx.doi.org/10.1111/j.1462-5822.2012.01836.x
 Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1462-5822.2012.01836.x
 DOI: https://doi.org/10.1111/j.1462-5822.2012.01836.x
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1584573317
Verknüpfungen:→ Zeitschrift

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