Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Warnefors, Maria [VerfasserIn]   i
 Mößinger, Katharina [VerfasserIn]   i
 Studer, Tania [VerfasserIn]   i
 Kaessmann, Henrik [VerfasserIn]   i
Titel:Sex-biased microRNA expression in mammals and birds reveals underlying regulatory mechanisms and a role in dosage compensation
Verf.angabe:Maria Warnefors, Katharina Mössinger, Jean Halbert, Tania Studer, John L. VandeBerg, Isa Lindgren, Amir Fallahshahroudi, Per Jensen and Henrik Kaessmann
E-Jahr:2017
Jahr:October 27, 2017
Umfang:13 S.
Fussnoten:Gesehen am 28.11.2018
Titel Quelle:Enthalten in: Genome research
Ort Quelle:Stanford, Calif. : HighWire Press, 1991
Jahr Quelle:2017
Band/Heft Quelle:27(2017), 12, Seite 1961-1973
ISSN Quelle:1549-5469
Abstract:Sexual dimorphism depends on sex-biased gene expression, but the contributions of microRNAs (miRNAs) have not been globally assessed. We therefore produced an extensive small RNA sequencing data set to analyze male and female miRNA expression profiles in mouse, opossum, and chicken. Our analyses uncovered numerous cases of somatic sex-biased miRNA expression, with the largest proportion found in the mouse heart and liver. Sex-biased expression is explained by miRNA-specific regulation, including sex-biased chromatin accessibility at promoters, rather than piggybacking of intronic miRNAs on sex-biased protein-coding genes. In mouse, but not opossum and chicken, sex bias is coordinated across tissues such that autosomal testis-biased miRNAs tend to be somatically male-biased, whereas autosomal ovary-biased miRNAs are female-biased, possibly due to broad hormonal control. In chicken, which has a Z/W sex chromosome system, expression output of genes on the Z Chromosome is expected to be male-biased, since there is no global dosage compensation mechanism that restores expression in ZW females after almost all genes on the W Chromosome decayed. Nevertheless, we found that the dominant liver miRNA, miR-122-5p, is Z-linked but expressed in an unbiased manner, due to the unusual retention of a W-linked copy. Another Z-linked miRNA, the male-biased miR-2954-3p, shows conserved preference for dosage-sensitive genes on the Z Chromosome, based on computational and experimental data from chicken and zebra finch, and acts to equalize male-to-female expression ratios of its targets. Unexpectedly, our findings thus establish miRNA regulation as a novel gene-specific dosage compensation mechanism.
DOI:doi:10.1101/gr.225391.117
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: http://dx.doi.org/10.1101/gr.225391.117
 Volltext: http://genome.cshlp.org/content/27/12/1961
 DOI: https://doi.org/10.1101/gr.225391.117
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1584575956
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68333401   QR-Code
zum Seitenanfang