Mechanismen der Zelltodregulation

• Verfasst von: Oliver Metzig, Marie [VerfasserIn]
• Verfasst von: Gdynia, Georg [VerfasserIn]
• Verfasst von: Roth, Wilfried [VerfasserIn]
• Titel: Mechanismen der Zelltodregulation
• Verf.angabe: M. Metzig, G. Gdynia, W. Roth
• E-Jahr: 2012
• Jahr: November 2012
• Umfang: 5 S.
• Fussnoten: First online: 26 September 2012 ; Gesehen am 28.11.2018
• Titel Quelle: Enthalten in: Der Pathologe
• Ort Quelle: Berlin : Springer, 1994
• Jahr Quelle: 2012
• Band/Heft Quelle: 33(2012), Supplement 2, Seite 241-245
• ISSN Quelle: 1432-1963
• DOI: doi:10.1007/s00292-012-1678-5
• Datenträger: Online-Ressource
• Sprache: ger
• Sach-SW: Apoptose
• Sach-SW: Apoptosis
• Sach-SW: Mitochondria
• Sach-SW: Mitochondrien
• Sach-SW: Necroptosis
• Sach-SW: Necrosis
• Sach-SW: Nekroptose
• Sach-SW: Nekrose
• Sach-SW: Tumorgenese
• Sach-SW: Tumorigenesis
• K10plus-PPN: 1584577053

Abstract

During tumorigenesis cancer cells acquire certain features allowing for sustained growth and circumvention of programmed cell death. For decades cancer research has been focused on the molecular mechanisms of apoptosis and how to overcome apoptosis resistance in tumor cells. Meanwhile, novel types of programmed cell death have turned out to be important for both physiological and pathological processes. Recent findings imply that induction of alternative forms of programmed cell death, such as necroptosis, might be used as a therapeutic approach to overcome therapy resistance in cancer.