Norepinephrine transporter blocker atomoxetine increases salivary alpha amylase

• Verfasst von: Warren, Christopher M. [VerfasserIn]
• Verfasst von: Brink, Ruud L. van den [VerfasserIn]
• Verfasst von: Bosch, Jos A. [VerfasserIn]
• Titel: Norepinephrine transporter blocker atomoxetine increases salivary alpha amylase
• Verf.angabe: Christopher M. Warren, Ruud L. van den Brink, Sander Nieuwenhuis, Jos A. Bosch
• E-Jahr: 2017
• Jahr: 31 January 2017
• Umfang: 4 S.
• Fussnoten: Gesehen am 28.11.2018
• Titel Quelle: Enthalten in: Psychoneuroendocrinology
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1975
• Jahr Quelle: 2017
• Band/Heft Quelle: 78(2017), Seite 233-236
• ISSN Quelle: 1873-3360
• DOI: doi:10.1016/j.psyneuen.2017.01.029
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Alpha amylase
• Sach-SW: Atomoxetine
• Sach-SW: Locus-coeruleus
• Sach-SW: Noradrenaline
• Sach-SW: Noradrenergic
• Sach-SW: Sympathetic
• Sach-SW: Yohimbine
• K10plus-PPN: 1584580917

Abstract

It has been suggested that central norepinephrine (NE) activity may be inferred from increases in salivary alpha-amylase (SAA), but data in favor of this proposition are limited. We administered 40mg of atomoxetine, a selective NE transporter blocker that increases central NE levels, to 24 healthy adult participants in a double-blind, placebo-controlled cross-over design. Atomoxetine administration significantly increased SAA secretion and concentrations at 75-180min after treatment (more than doubling baseline levels). Consistent with evidence that elevation in central NE is a co-determinant of hypothalamic-pituitary-adrenal axis activity, salivary cortisol also approximately doubled at the same time points. Moreover, changes in salivary cortisol positively correlated with SAA (0.44<rho<0.56), bolstering the position that the origin of the changes in SAA reflect central NE. This work points toward the potential value of SAA as an inexpensive and non-invasive procedure to obtain information about activation of the central NE system.