Understanding diabetic polyneuropathy and longevity

• Verfasst von: Mendler, Michael [VerfasserIn]
• Verfasst von: Schlotterer, Andrea [VerfasserIn]
• Verfasst von: Morcos, Michael [VerfasserIn]
• Verfasst von: Nawroth, Peter Paul [VerfasserIn]
• Titel: Understanding diabetic polyneuropathy and longevity
• Titelzusatz: what can we learn from the nematode caenorhabditis elegans?
• Verf.angabe: M. Mendler, A. Schlotterer, M. Morcos, P.P. Nawroth
• E-Jahr: 2012
• Jahr: 8 March 2012
• Umfang: 2 S.
• Fussnoten: Gesehen am 28.11.2018
• Titel Quelle: Enthalten in: Experimental and clinical endocrinology & diabetes
• Ort Quelle: Stuttgart [u.a.] : Thieme, 1983
• Jahr Quelle: 2012
• Band/Heft Quelle: 120(2012), 4, Seite 182-183
• ISSN Quelle: 1439-3646
• DOI: doi:10.1055/s-0032-1304570
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1584589019

Abstract

Pathogenesis of late diabetic complications is influenced by a complex interplay of multiple exogenous and intrinsic factors. The well characterised nematode Caenorhabditis elegans is an ideal model to study causes of diabetic polyneuropathy because of its easily accessible nervous system. A repertoire of methods allows the assessment of both morphological and functional glucotoxic damages as well as reduction of lifespan, thereby helping to examine the influence of different pathways and mechanisms on neurodegeneration. Its insulin signalling system allows to directly visualize effects of insulin on high glucose induced neuronal damage, leading to a better understanding of diabetic polyneuropathy.