Renal BOLD-MRI does not reflect renal function in chronic kidney disease

• Verfasst von: Michaely, Henrik J. M. [VerfasserIn]
• Verfasst von: Metzger, Linda Madeleine [VerfasserIn]
• Verfasst von: Haneder, Stefan [VerfasserIn]
• Verfasst von: Hansmann, Jan [VerfasserIn]
• Verfasst von: Schönberg, Stefan [VerfasserIn]
• Verfasst von: Attenberger, Ulrike [VerfasserIn]
• Titel: Renal BOLD-MRI does not reflect renal function in chronic kidney disease
• Verf.angabe: Henrik J. Michaely, Linda Metzger, Stefan Haneder, Jan Hansmann, Stefan O. Schoenberg, Ulrike I. Attenberger
• E-Jahr: 2012
• Jahr: 1 April 2012
• Umfang: 6 S.
• Fussnoten: Gesehen am 29.11.2018
• Titel Quelle: Enthalten in: Kidney international
• Ort Quelle: New York, NY : Elsevier, 1972
• Jahr Quelle: 2012
• Band/Heft Quelle: 81(2012), 7, Seite 684-689
• ISSN Quelle: 1523-1755
• DOI: doi:10.1038/ki.2011.455
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: 1.5T
• Sach-SW: 3.0T
• Sach-SW: BOLD
• Sach-SW: chronic renal failure
• Sach-SW: functional imaging
• Sach-SW: magnetic resonance
• Sach-SW: renal function
• K10plus-PPN: 1584618833

Abstract

Renal blood oxygen level-dependent magnetic resonance imaging (BOLD-MRI) is a noninvasive fast technique to characterize renal function. Here we evaluated the impact of renal function on the relaxation rate (R2*) in the cortex and medulla to provide baseline data for further use of renal BOLD-MRI. This parameter was evaluated in 400 patients scheduled for abdominal imaging who underwent transversal blood oxygen level-dependent measurements with a multi-echo gradient-echo sequence with 12 echo times. The loss of phase coherence (T2*) maps were generated in which kidney regions of interest were selected to differentiate the medulla and cortex, and R2* was equated to 1/T2*. Individual R2* values were, in turn, correlated to the eGFR (MDRD formula of 280 patients with available serum creatinine measurements), age, and gender each for 1.5 and 3.0T field-strength scans of 342 patients. At both the field strengths, no significant differences in R2* of the cortex and medulla were found between patient gender, age, eGFR, or between different stages of chronic kidney disease determined using the KDOQI system. Thus, BOLD-MRI of a non-specific patient population failed to discriminate between the patients with various stages of chronic kidney disease.