| |  Online-Ressource |
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| Verfasst von: | Erben, Philipp [VerfasserIn]  |
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| | Nowak, Daniel [VerfasserIn] |
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| | Sauer, Christian [VerfasserIn] |
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| | Ströbel, Philipp [VerfasserIn] |
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| | Hofmann, Wolf-Karsten [VerfasserIn] |
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| | Hofheinz, Ralf-Dieter [VerfasserIn] |
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| | Hohenberger, Peter [VerfasserIn] |
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| | Kasper, Bernd [VerfasserIn] |
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| Titel: | Molecular analysis of desmoid tumors with a high-density single-nucleotide polymorphism array identifies new molecular candidate lesions |
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| Verf.angabe: | Philipp Erben, Daniel Nowak, Christian Sauer, Philipp Ströbel, Wolf-Karsten Hofmann, Ralf-Dieter Hofheinz, Peter Hohenberger, Bernd Kasper |
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| E-Jahr: | 2012 |
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| Jahr: | October 22, 2012 |
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| Umfang: | 5 S. |
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| Fussnoten: | Gesehen am 29.11.2018 |
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| Titel Quelle: | Enthalten in: Onkologie |
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| Ort Quelle: | Basel : Karger, 1978 |
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| Jahr Quelle: | 2012 |
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| Band/Heft Quelle: | 35(2012), 11, Seite 684-688 |
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| ISSN Quelle: | 1423-0240 |
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| Abstract: | Background: Desmoid tumors are neoplastic proliferations of connective tissues. The mutation status of the gene coding for catenin (cadherin-associated protein) beta 1 (CTNNB1) and trisomy 8 on the chromosomal level have been described to have prognostic relevance. Patients and methods: In order to elucidate new molecular mechanisms underlying these tumors, we carried out a molecular analysis with a genome-wide human high-density single-nucleotide polymorphism (SNP) array, in 9 patients. Results: Single samples showed numerical aberrations on chromosomes (Chrs) 20 and 6 with either trisomy 20 or monosomy 6. No trisomy 8 could be detected. Recurrent heterozygous deletions were found in Chr 5q (including the APC gene locus, n = 3) and Chr 8p23 (n = 4, containing coding regions for the potential tumor suppressor gene CSMD1). This novel deletion in 8p23 showed an association with local recurrence. In addition, structural chromosomal changes (gain of Chrs 8 and 20) were found in a minority of cases. Conclusion: The genomic alteration affecting the candidate gene CSMD1 could be important in the development of desmoid tumors. |
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| DOI: | doi:10.1159/000343744 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://dx.doi.org/10.1159/000343744 |
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| | Volltext: https://www.karger.com/Article/FullText/343744 |
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| | DOI: https://doi.org/10.1159/000343744 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Bibliogr. Hinweis: | Erscheint auch als : Druck-Ausgabe: Molecular analysis of desmoid tumors with a high-density single-nucleotide polymorphism array identifies new molecular candidate lesions. - 2012 |
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| K10plus-PPN: | 1584624159 |
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| Verknüpfungen: | → Zeitschrift |
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Molecular analysis of desmoid tumors with a high-density single-nucleotide polymorphism array identifies new molecular candidate lesions / Erben, Philipp [VerfasserIn]; October 22, 2012 (Online-Ressource)
