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| Verfasst von: | Fichtner, Alexander [VerfasserIn]  |
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| | Süsal, Caner [VerfasserIn] |
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| | Höcker, Britta [VerfasserIn] |
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| | Rieger, Susanne [VerfasserIn] |
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| | Waldherr, Rüdiger [VerfasserIn] |
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| | Westhoff, Jens [VerfasserIn] |
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| | Sander, Anja [VerfasserIn] |
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| | Opelz, Gerhard [VerfasserIn] |
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| | Tönshoff, Burkhard [VerfasserIn] |
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| Titel: | Association of C1q-fixing DSA with late graft failure in pediatric renal transplant recipients |
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| Verf.angabe: | Alexander Fichtner, Caner Süsal, Britta Höcker, Susi Rieger, Rüdiger Waldherr, Jens H. Westhoff, Anja Sander, Gerhard Opelz, Burkhard Tönshoff |
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| E-Jahr: | 2016 |
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| Jahr: | 29 February 2016 |
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| Umfang: | 10 S. |
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| Fussnoten: | Gesehen am 03.12.2018 |
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| Titel Quelle: | Enthalten in: Pediatric nephrology |
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| Ort Quelle: | Berlin : Springer, 1987 |
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| Jahr Quelle: | 2016 |
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| Band/Heft Quelle: | 31(2016), 7, Seite 1157-1166 |
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| ISSN Quelle: | 1432-198X |
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| Abstract: | BackgroundWe investigated the prognostic value of overall and complement-binding donor-specific HLA antibodies (DSA) in pediatric patients undergoing clinically indicated graft biopsies and their association with graft outcome and specific histological lesions.MethodsSera of 62 patients at time of indication biopsy ≥1 year posttransplant were assessed for DSA and C1q-fixing DSA by single-antigen bead (SAB) technology.ResultsTwenty-six patients (42 %) were DSA-positive at time of indication biopsy and nine (15 %) were C1q-positive. At 4 years postbiopsy, patients with C1q-positivity had a low graft survival (11 %) compared to DSA-positive, C1q-negative patients (82 %, p = 0.001) and to DSA-negative patients (88 %, p < 0.001). The majority (89 %) of C1q-positive patients were diagnosed with active chronic antibody-mediated rejection (ABMR). C1q DSA-positivity [adjusted hazard ratio (HR) 6.35], presence of transplant glomerulopathy (HR 9.54), and estimated glomerular filtration rate (eGFR) at the time of indication biopsy (HR 0.91) were risk factors for subsequent graft loss.ConclusionsThe presence of C1q-positive DSA in the context of an indication biopsy identifies a subgroup of pediatric renal transplant recipients with a markedly increased risk of subsequent graft loss. Because a fraction of DSA-positive patients escape rejection or graft dysfunction, the C1q assay increases the specificity of a positive DSA result regarding unfavorable transplant outcome. |
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| DOI: | doi:10.1007/s00467-016-3322-8 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://dx.doi.org/10.1007/s00467-016-3322-8 |
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| | Volltext: https://doi.org/10.1007/s00467-016-3322-8 |
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| | DOI: https://doi.org/10.1007/s00467-016-3322-8 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | C1q-binding donor-specific antibodies |
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| | Donor-specific antibodies |
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| | Graft failure |
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| | Indication biopsy |
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| | Pediatrics |
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| | Renal transplantation |
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| K10plus-PPN: | 1584730188 |
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| Verknüpfungen: | → Zeitschrift |
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Association of C1q-fixing DSA with late graft failure in pediatric renal transplant recipients / Fichtner, Alexander [VerfasserIn]; 29 February 2016 (Online-Ressource)
