Outcome of heavily pretreated recurrent oral squamous cell carcinoma after salvage resection

• Verfasst von: Horn, Dominik [VerfasserIn]
• Verfasst von: Bodem, Jens [VerfasserIn]
• Verfasst von: Freudlsperger, Christian [VerfasserIn]
• Verfasst von: Zittel, Sven [VerfasserIn]
• Verfasst von: Weichert, Wilko [VerfasserIn]
• Verfasst von: Hoffmann, Jürgen [VerfasserIn]
• Verfasst von: Freier, Kolja [VerfasserIn]
• Titel: Outcome of heavily pretreated recurrent oral squamous cell carcinoma after salvage resection
• Titelzusatz: a monocentric retrospective analysis
• Verf.angabe: Dominik Horn, Jens Bodem, Christian Freudlsperger, Sven Zittel, Wilko Weichert, Jürgen Hoffmann, Kolja Freier
• E-Jahr: 2016
• Jahr: August 2016
• Umfang: 6 S.
• Fussnoten: Gesehen am 03.12.2018
• Titel Quelle: Enthalten in: Journal of cranio-maxillofacial surgery
• Ort Quelle: Oxford [u.a.] : Elsevier, 1987
• Jahr Quelle: 2016
• Band/Heft Quelle: 44(2016), 8, Seite 1061-1066
• ISSN Quelle: 1878-4119
• DOI: doi:10.1016/j.jcms.2016.05.005
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Heavy pretreatment
• Sach-SW: Microvascular reconstruction
• Sach-SW: Recurrent oral squamous cell carcinoma
• Sach-SW: Salvage surgery
• K10plus-PPN: 158473583X

Abstract

Purpose The goals of the present study were to analyze survival data of patients who received salvage surgery due to recurrent oral squamous cell carcinoma (OSCC) of the oral cavity with curative intent, and to investigate the feasibility of microvascular flap reconstruction in a heavily pretreated patient cohort. Material and methods A total of 32 patients who received salvage surgery due to recurrent OSCC were included. The cohort was analyzed in regard to relevant clinical and pathological features. Survival was estimated by using Kaplan-Meier analysis and verified in a multivariate Cox regression model. Results All patients recovered well from surgery. The most common severe complication was free flap failure in 7 patients (24.1%). R0-resection was achieved in 16 patients (50%). Univariate Kaplan-Meier analysis showed that the estimated overall survival and disease-free survival of all patients after 24 months were 37.8% and 30.9%, respectively. Multivariate testing identified R1-resection was the only independent predictor of treatment failure. Conclusion Salvage surgery is the only potential curative treatment option in recurrent OSCC. Microvascular reconstruction is feasible in heavily pretreated patients, but it is associated with a higher free flap failure rate. Recurrent OSCC in heavily pretreated patients shows different biological behavior. Further prospective clinical and molecular studies are needed to develop a better molecular understanding of recurrent OSCC and the best and safest individual therapeutic strategy.