Towards a compendium of essential genes

• Verfasst von: Zhan, Tianzuo [VerfasserIn]
• Verfasst von: Boutros, Michael [VerfasserIn]
• Titel: Towards a compendium of essential genes
• Titelzusatz: from model organisms to synthetic lethality in cancer cells
• Verf.angabe: Tianzuo Zhan and Michael Boutros
• Jahr: 2016
• Umfang: 12 S.
• Fussnoten: Published online: 01 Dec 2015 ; Gesehen am 06.12.2018
• Titel Quelle: Enthalten in: Critical reviews in biochemistry and molecular biology
• Ort Quelle: Abingdon : Taylor & Francis Group, 1989
• Jahr Quelle: 2016
• Band/Heft Quelle: 51(2016), 2, Seite 74-85
• ISSN Quelle: 1549-7798
• DOI: doi:10.3109/10409238.2015.1117053
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Cancer research
• Sach-SW: CRISPR/Cas9
• Sach-SW: essential genes
• Sach-SW: genetic interaction
• Sach-SW: RNAi
• Sach-SW: screening
• Sach-SW: synthetic lethality
• K10plus-PPN: 1584899824

Abstract

Essential genes are defined by their requirement to sustain life in cells or whole organisms. The systematic identification of essential gene sets not only allows insights into the fundamental building blocks of life, but may also provide novel therapeutic targets in oncology. The discovery of essential genes has been tightly linked to the development and deployment of various screening technologies. Here, we describe how gene essentiality was addressed in different eukaryotic model organisms, covering a range of organisms from yeast to mouse. We describe how increasing knowledge of evolutionarily divergent genomes facilitate identification of gene essentiality across species. Finally, the impact of gene essentiality and synthetic lethality on cancer research and the clinical translation of screening results are highlighted.