| |  Online-Ressource |
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| Verfasst von: | Berger, Andreas W. [VerfasserIn]  |
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| | Hackert, Thilo [VerfasserIn] |
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| | Strobel, Oliver [VerfasserIn] |
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| | Büchler, Markus W. [VerfasserIn] |
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| Titel: | Detection of hot-spot mutations in circulating cell-free DNA from patients with intraductal papillary mucinous neoplasms of the pancreas |
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| Verf.angabe: | Andreas W. Berger, Daniel Schwerdel, Ivan G. Costa, Thilo Hackert, Oliver Strobel, Sandra Lam, Thomas F. Barth, Bernd Schröppel, Alexander Meining, Markus W. Büchler, Martin Zenke, Patrick C. Hermann, Thomas Seufferlein, and Alexander Kleger |
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| E-Jahr: | 2016 |
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| Jahr: | August 2016 |
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| Umfang: | 4 S. |
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| Fussnoten: | Gesehen am 06.12.2018 |
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| Titel Quelle: | Enthalten in: Gastroenterology |
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| Ort Quelle: | New York, NY : Elsevier, 1949 |
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| Jahr Quelle: | 2016 |
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| Band/Heft Quelle: | 151(2016), 2, Seite 267-270 |
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| ISSN Quelle: | 1528-0012 |
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| Abstract: | Intraductal papillary mucinous neoplasms (IPMNs) are the most frequent cystic pancreatic tumors. Little is known about their molecular alterations, but mutations in GNAS have been reported to promote IPMN formation. A tumor-derived fraction of circulating cell-free DNA (cfDNA), isolated from blood samples, contains many of the same mutations as the primary tumor, and could be a tool for noninvasive disease monitoring. We found that the total amount of cfDNA can discriminate between individuals without pancreatic lesions (controls) and patients with Fukuoka-negative branch-duct IPMN or pancreatic cancer. Furthermore, we detected GNAS mutations in cfDNA from patients with IPMN, but not in patients with serous cystadenoma or controls. Analyses of cfDNA might therefore be used in the diagnosis of patients with IPMN or in monitoring disease progression. |
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| DOI: | doi:10.1053/j.gastro.2016.04.034 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://dx.doi.org/10.1053/j.gastro.2016.04.034 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S0016508516343384 |
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| | DOI: https://doi.org/10.1053/j.gastro.2016.04.034 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Biomarker |
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| | Diagnostic |
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| | Genetic |
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| | IPMN |
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| | PDAC |
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| | Prognostic Factor |
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| K10plus-PPN: | 1584911301 |
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| Verknüpfungen: | → Zeitschrift |
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Detection of hot-spot mutations in circulating cell-free DNA from patients with intraductal papillary mucinous neoplasms of the pancreas / Berger, Andreas W. [VerfasserIn]; August 2016 (Online-Ressource)
