| Online-Ressource |
Verfasst von: | Brinkmann, Eva-Maria [VerfasserIn]  |
| Kumar, Rahul [VerfasserIn]  |
| Steinbeisser, Herbert [VerfasserIn]  |
| Kaufmann, Lilian [VerfasserIn]  |
| Özbek, Suat [VerfasserIn]  |
Titel: | Secreted frizzled-related protein 2 (sFRP2) redirects non-canonical Wnt signaling from Fz7 to Ror2 during vertebrate gastrulation |
Verf.angabe: | Eva-Maria Brinkmann, Benjamin Mattes, Rahul Kumar, Anja I. H. Hagemann, Dietmar Gradl, Steffen Scholpp, Herbert Steinbeisser, Lilian T. Kaufmann, and Suat Özbek |
E-Jahr: | 2016 |
Jahr: | April 20, 2016 |
Umfang: | 13 S. |
Fussnoten: | Gesehen am 06.12.2018 |
Titel Quelle: | Enthalten in: The journal of biological chemistry |
Ort Quelle: | Bethesda, Md. : ASBMB Publications, 1905 |
Jahr Quelle: | 2016 |
Band/Heft Quelle: | 291(2016), 26, Seite 13730-13742 |
ISSN Quelle: | 1083-351X |
Abstract: | Convergent extension movements during vertebrate gastrulation require a balanced activity of non-canonical Wnt signaling pathways, but the factors regulating this interplay on the molecular level are poorly characterized. Here we show that sFRP2, a member of the secreted frizzled-related protein (sFRP) family, is required for morphogenesis and papc expression during Xenopus gastrulation. We further provide evidence that sFRP2 redirects non-canonical Wnt signaling from Frizzled 7 (Fz7) to the receptor tyrosine kinase-like orphan receptor 2 (Ror2). During this process, sFRP2 promotes Ror2 signal transduction by stabilizing Wnt5a-Ror2 complexes at the membrane, whereas it inhibits Fz7 signaling, probably by blocking Fz7 receptor endocytosis. The cysteine-rich domain of sFRP2 is sufficient for Ror2 activation, and related sFRPs can substitute for this function. Notably, direct interaction of the two receptors via their cysteine-rich domains also promotes Ror2-mediated papc expression but inhibits Fz7 signaling. We propose that sFRPs can act as a molecular switch, channeling the signal input for different non-canonical Wnt pathways during vertebrate gastrulation. |
DOI: | doi:10.1074/jbc.M116.733766 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://dx.doi.org/10.1074/jbc.M116.733766 |
| Volltext: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919455/ |
| DOI: https://doi.org/10.1074/jbc.M116.733766 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1584913134 |
Verknüpfungen: | → Zeitschrift |
Secreted frizzled-related protein 2 (sFRP2) redirects non-canonical Wnt signaling from Fz7 to Ror2 during vertebrate gastrulation / Brinkmann, Eva-Maria [VerfasserIn]; April 20, 2016 (Online-Ressource)