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| Verfasst von: | Fritz, Jasmin [VerfasserIn]  |
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| | Brecht, Ramona [VerfasserIn] |
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| | Nachtigall, Ines [VerfasserIn] |
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| | Werner, Jens [VerfasserIn] |
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| | Bazhin, Alexandr V. [VerfasserIn] |
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| Titel: | In vitro immunomodulatory properties of gemcitabine alone and in combination with interferon-alpha |
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| Mitwirkende: | Karakhanova, Svetlana |
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| Verf.angabe: | Jasmin Fritz, Svetlana Karakhanova, Ramona Brecht, Ines Nachtigall, Jens Werner, Alexandr V. Bazhin |
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| E-Jahr: | 2015 |
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| Jahr: | November 2015 |
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| Umfang: | 9 S. |
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| Fussnoten: | Gesehen am 06.12.2018 |
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| Titel Quelle: | Enthalten in: Immunology letters |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1979 |
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| Jahr Quelle: | 2015 |
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| Band/Heft Quelle: | 168(2015), 1, Seite 111-119 |
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| ISSN Quelle: | 1879-0542 |
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| Abstract: | In general, conventional chemotherapy is associated with significant toxicity leading to immunosuppression manifesting mainly in the lymphocyte depletion. This immunosuppression promotes tumor growth and elicits the tumor cell dissemination. However, chemotherapy can be immune stimulative especially in combination with an immunotherapy. In this work, we investigated in vitro effects of gemcitabine alone and in combination with interferon-alpha on splenocytes obtained from healthy and pancreatic carcinoma bearing mice. We showed that gemcitabine alone depletes the regulatory T cells in the splenocyte culture. Gemcitabine in combination with interferon-alpha demonstrated some immunomodulatory features, but these effects were interferon-alpha dependent. We concluded that combination of both drugs induces rather cumulative effects, supposing that these therapeutic could be applied together for a chemo-immunotherapy. |
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| DOI: | doi:10.1016/j.imlet.2015.09.017 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://dx.doi.org/10.1016/j.imlet.2015.09.017 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S0165247815300419 |
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| | DOI: https://doi.org/10.1016/j.imlet.2015.09.017 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Chemotherapy |
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| | Gemcitabine |
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| | Immunomodulation |
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| | Interferon-alpha |
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| | Pancreatic adenocarcinoma |
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| K10plus-PPN: | 1584914181 |
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| Verknüpfungen: | → Zeitschrift |
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In vitro immunomodulatory properties of gemcitabine alone and in combination with interferon-alpha / Fritz, Jasmin [VerfasserIn]; November 2015 (Online-Ressource)
