Advanced radiation techniques in the treatment of esthesioneuroblastoma

• Verfasst von: Liermann, Jakob [VerfasserIn]
• Verfasst von: Syed, Mustafa [VerfasserIn]
• Verfasst von: Held, Thomas [VerfasserIn]
• Verfasst von: Bernhardt, Denise [VerfasserIn]
• Verfasst von: Plinkert, Peter K. [VerfasserIn]
• Verfasst von: Jungk, Christine [VerfasserIn]
• Verfasst von: Unterberg, Andreas [VerfasserIn]
• Verfasst von: Rieken, Stefan [VerfasserIn]
• Verfasst von: Debus, Jürgen [VerfasserIn]
• Verfasst von: Herfarth, Klaus [VerfasserIn]
• Verfasst von: Adeberg, Sebastian [VerfasserIn]
• Titel: Advanced radiation techniques in the treatment of esthesioneuroblastoma
• Titelzusatz: a 7-year single-institution’s clinical experience
• Verf.angabe: Jakob Liermann, Mustafa Syed, Thomas Held, Denise Bernhardt, Peter Plinkert, Christine Jungk, Andreas Unterberg, Stefan Rieken, Jürgen Debus, Klaus Herfarth and Sebastian Adeberg
• E-Jahr: 2018
• Jahr: 20 November 2018
• Umfang: 11 S.
• Fussnoten: Gesehen am 18.12.2018
• Titel Quelle: Enthalten in: Cancers
• Ort Quelle: Basel : MDPI, 2009
• Jahr Quelle: 2018
• Band/Heft Quelle: 10(2018), 11, Artikel-ID 457
• ISSN Quelle: 2072-6694
• DOI: doi:10.3390/cancers10110457
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: carbon ion radiation
• Sach-SW: esthesioneuroblastoma
• Sach-SW: olfactory neuroblastoma
• Sach-SW: particle therapy
• Sach-SW: radiotherapy
• K10plus-PPN: 1585658405
• K10plus-PPN:
  Universitätsbibliothek
• Lokale URL UB: Zum Volltext

Abstract

(1) Background: Esthesioneuroblastoma (ENB) is a rare tumor entity originating from the olfactory neuroepithelium. There is a scarcity of data about different treatment strategies. Intensity modulated radiotherapy (IMRT) and carbon ion radiotherapy (CIRT) are advanced radiation techniques that might improve local tumor control. (2) Methods: This retrospective analysis contained 17 patients with ENB (Kadish stage ≥ C: 88%; n = 15). Four patients had already undergone previous radiotherapy (RT). The treatment consisted of either IMRT (n = 5), CIRT (n = 4) or a combination of both techniques (n = 8). Median follow-up was 29 months. (3) Results: In patients that had not been irradiated before (n = 13), calculated overall survival (OS) and progression free survival (PFS) rates after 48 months were 100% and 81% respectively (Kaplan-Meier estimates). Two of four patients that underwent reirradiation died after RT, presumably due to tumor progression. Besides common toxicities, five patients (30%) showed mostly asymptomatic radiation-induced brain changes, most likely due to a disturbance of the blood-brain barrier. (4) Conclusions: Our results demonstrate that IMRT, CIRT, a combined approach of IMRT and CIRT as well as reirradiation with CIRT seem to be feasible and effective treatment methods in ENB.