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Verfasst von:Hegewald, Aldemar Andres [VerfasserIn]   i
 Tsagogiorgas, Charalambos [VerfasserIn]   i
 Shenegelegn Mern, Demissew [VerfasserIn]   i
Titel:Enhancing tissue repair in annulus fibrosus defects of the intervertebral disc
Titelzusatz:analysis of a bio-integrative annulus implant in an in-vivo ovine model
Verf.angabe:Aldemar Andres Hegewald, Fabian Medved, Daxiong Feng, Charalambos Tsagogiorgas, Anja Beierfuß, Genevieve Ama Kyremaa Schindler, Marcus Trunk, Christian Kaps, Demissew Shenegelegn Mern and Claudius Thomé
E-Jahr:2015
Jahr:April 2015
Umfang:10 S.
Fussnoten:Gesehen am 19.12.2018 ; First published: 12 November 2013
Titel Quelle:Enthalten in: Journal of tissue engineering and regenerative medicine
Ort Quelle:London : Hindawi Limited, 2007
Jahr Quelle:2015
Band/Heft Quelle:9(2015), 4, Seite 405-414
ISSN Quelle:1932-7005
Abstract:Annulus fibrosus repair techniques for the intervertebral disc (IVD) address the unsolved problem of reherniation after IVD herniation and might facilitate the development of nucleus pulposus replacement techniques for IVD diseases. This study investigates the suitability of a bio-integrative annulus implant.Standardized box defects were applied to the annulus L3/4 and L4/5 of 16 sheep, followed by randomized insertion of the textile polyglycolic acid/polyvinylidene fluoride annulus implant in one of the defects. Explantation was conducted after 2, 6 and 12 weeks, followed by provocative pressure testing and histological analysis. At 2 weeks’ follow-up, all specimens of the control defect group demonstrated uncontained herniated nucleus pulposus tissue in the annulus defects. For the treated specimens, the annulus implant consistently provided an effective barrier for herniating nucleus pulposus tissue, with no implant dislocation at all time-points. After 2 weeks, a homogeneous cell infiltration of the annulus implant was observed, leading to a progressive directional matrix build-up. Repair tissue thickness was significantly stronger with the annulus implant at all follow-ups (p < 0.01). No pronounced foreign body reaction and no difference in the amount of supra-annular scar tissue over the defect sites were observed. The implantation procedure inflicted annulus damage adjacent to the defect. At later time-points, however, no difference in comparison with the control defect group was evident. The investigated biointegrative annulus implant showed promising results with regard to biointegration, enhancement of repair tissue and function as a mechanical barrier in an ovine model.
DOI:doi:10.1002/term.1831
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: http://dx.doi.org/10.1002/term.1831
 kostenfrei: Volltext: https://onlinelibrary-wiley-com.ezproxy.medma.uni-heidelberg.de/doi/abs/10.1002/term.1831
 DOI: https://doi.org/10.1002/term.1831
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:annulus fibrosus
 biomaterial
 disc herniation
 intervertebral disc
 regeneration
 spine surgery
K10plus-PPN:1585748560
Verknüpfungen:→ Zeitschrift

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