RIPping the skin apart

• Verfasst von: Panayotova Dimitrova, Diana [VerfasserIn]
• Verfasst von: Feoktistova, Maria [VerfasserIn]
• Verfasst von: Leverkus, Martin [VerfasserIn]
• Titel: RIPping the skin apart
• Titelzusatz: necroptosis signaling in toxic epidermal necrolysis
• Verf.angabe: Diana Panayotova-Dimitrova, Maria Feoktistova, Martin Leverkus
• E-Jahr: 2015
• Jahr: August 2015
• Umfang: 4 S.
• Fussnoten: Available online 8 December 2015 ; Gesehen am 07.01.2019
• Titel Quelle: Enthalten in: The journal of investigative dermatology
• Ort Quelle: Amsterdam : Elsevier, 1938
• Jahr Quelle: 2015
• Band/Heft Quelle: 135(2015), 8, Seite 1940-1943
• ISSN Quelle: 1523-1747
• DOI: doi:10.1038/jid.2015.159
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1585963054

Abstract

Toxic epidermal necrolysis (TEN) is a rare but potentially fatal drug hypersensitivity reaction. Although a number of pathophysiological hints have been identified over the past decade, details of the effector mechanisms within the skin remain obscure. A novel study by Kim et al. now sheds light on its pathophysiology. The investigators demonstrate convincingly that receptor-interacting kinase 3 (RIPK3) levels are upregulated substantially in the lesional skin of patients with TEN and that this is followed by the generation of reactive oxygen species, activation of mixed lineage kinase-like protein, and subsequent necroptotic cell death of keratinocytes. These data suggest that therapies that interfere with RIPK3 activation and necroptosis induction could benefit patients with TEN.