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| Verfasst von: | Khan, Muzamil Majid [VerfasserIn]  |
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| | Wild, Franziska [VerfasserIn] |
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| | Labeit, Dittmar [VerfasserIn] |
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| | Labeit, Siegfried [VerfasserIn] |
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| | Rudolf, Rüdiger [VerfasserIn] |
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| Titel: | Sympathetic innervation controls homeostasis of neuromuscular junctions in health and disease |
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| Verf.angabe: | Muzamil Majid Khan, Danilo Lustrino, Willian A. Silveira, Franziska Wild, Tatjana Straka, Yasmin Issop, Emily O’Connor, Dan Cox, Markus Reischl, Till Marquardt, Dittmar Labeit, Siegfried Labeit, Evelyne Benoit, Jordi Molgó, Hanns Lochmüller, Veit Witzemann, Isis C. Kettelhut, Luiz C.C. Navegantes, Tullio Pozzan, and Rüdiger Rudolf |
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| E-Jahr: | 2016 |
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| Jahr: | January 19, 2016 |
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| Umfang: | 5 S. |
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| Fussnoten: | Gesehen am 14.01.2019 |
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| Titel Quelle: | Enthalten in: National Academy of Sciences (Washington, DC)Proceedings of the National Academy of Sciences of the United States of America |
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| Ort Quelle: | Washington, DC : National Acad. of Sciences, 1915 |
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| Jahr Quelle: | 2016 |
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| Band/Heft Quelle: | 113(2016), 3, Seite 746-750 |
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| ISSN Quelle: | 1091-6490 |
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| Abstract: | The distribution and function of sympathetic innervation in skeletal muscle have largely remained elusive. Here we demonstrate that sympathetic neurons make close contact with neuromuscular junctions and form a network in skeletal muscle that may functionally couple different targets including blood vessels, motor neurons, and muscle fibers. Direct stimulation of sympathetic neurons led to activation of muscle postsynaptic β2-adrenoreceptor (ADRB2), cAMP production, and import of the transcriptional coactivator peroxisome proliferator-activated receptor γ-coactivator 1α (PPARGC1A) into myonuclei. Electrophysiological and morphological deficits of neuromuscular junctions upon sympathectomy and in myasthenic mice were rescued by sympathicomimetic treatment. In conclusion, this study identifies the neuromuscular junction as a target of the sympathetic nervous system and shows that sympathetic input is crucial for synapse maintenance and function. |
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| DOI: | doi:10.1073/pnas.1524272113 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://dx.doi.org/10.1073/pnas.1524272113 |
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| | Volltext: https://www-pnas-org.ezproxy.medma.uni-heidelberg.de/content/113/3/746 |
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| | DOI: https://doi.org/10.1073/pnas.1524272113 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | beta-agonists |
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| | cAMP |
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| | myasthenia |
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| | neuromuscular junction |
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| | sympathetic neurons |
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| K10plus-PPN: | 1586174851 |
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| Verknüpfungen: | → Zeitschrift |
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Sympathetic innervation controls homeostasis of neuromuscular junctions in health and disease / Khan, Muzamil Majid [VerfasserIn]; January 19, 2016 (Online-Ressource)
