Cellular pathways in response to ionizing radiation and their targetability for tumor radiosensitization

• Verfasst von: Maier, Patrick [VerfasserIn]
• Verfasst von: Hartmann, Linda [VerfasserIn]
• Verfasst von: Wenz, Frederik [VerfasserIn]
• Verfasst von: Herskind, Carsten [VerfasserIn]
• Titel: Cellular pathways in response to ionizing radiation and their targetability for tumor radiosensitization
• Verf.angabe: Patrick Maier, Linda Hartmann, Frederik Wenz and Carsten Herskind
• Umfang: 32$p17(2016,1) Artikel-Nummer 102, 32 Seiten S.
• Fussnoten: Gesehen am 15.01.2019
• Titel Quelle: Enthalten in: International journal of molecular sciences
• Jahr Quelle: 2016
• Band/Heft Quelle: 17(2016), 1
• ISSN Quelle: 1422-0067
• ISSN Quelle: 1661-6596
• DOI: doi:10.3390/ijms17010102
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1586226061

Abstract

During the last few decades, improvements in the planning and application of radiotherapy in combination with surgery and chemotherapy resulted in increased survival rates of tumor patients. However, the success of radiotherapy is impaired by two reasons: firstly, the radioresistance of tumor cells and, secondly, the radiation-induced damage of normal tissue cells located in the field of ionizing radiation. These limitations demand the development of drugs for either radiosensitization of tumor cells or radioprotection of normal tissue cells. In order to identify potential targets, a detailed understanding of the cellular pathways involved in radiation response is an absolute requirement. This review describes the most important pathways of radioresponse and several key target proteins for radiosensitization.