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Verfasst von:Meyer, Bernhard M. [VerfasserIn]   i
 Banaschewski, Tobias [VerfasserIn]   i
 Flor, Herta [VerfasserIn]   i
 Rietschel, Marcella [VerfasserIn]   i
Titel:Oppositional COMT Val158Met effects on resting state functional connectivity in adolescents and adults
Verf.angabe:Bernhard M. Meyer, Julia Huemer, Ulrich Rabl, Roland N. Boubela, Klaudius Kalcher, Andreas Berger, Tobias Banaschewski, Gareth Barker, Arun Bokde, Christian Büchel, Patricia Conrod, Sylvane Desrivières, Herta Flor, Vincent Frouin, Jurgen Gallinat, Hugh Garavan, Andreas Heinz, Bernd Ittermann, Tianye Jia, Mark Lathrop, Jean-Luc Martinot, Frauke Nees, Marcella Rietschel, Michael N. Smolka, Lucie Bartova, Ana Popovic, Christian Scharinger, Harald H. Sitte, Hans Steiner, Max H. Friedrich, Siegfried Kasper, Thomas Perkmann, Nicole Praschak-Rieder, Helmuth Haslacher, Harald Esterbauer, Ewald Moser, Gunter Schumann, Lukas Pezawas
Jahr:2016
Jahr des Originals:2014
Umfang:12 S.
Fussnoten:Gesehen am 16.01.2019 ; Published online: 16 October 2014
Titel Quelle:Enthalten in: Brain structure & function
Ort Quelle:Berlin : Springer, 2007
Jahr Quelle:2016
Band/Heft Quelle:221(2016), 1, Seite 103-114
ISSN Quelle:1863-2661
Abstract:Prefrontal dopamine levels are relatively increased in adolescence compared to adulthood. Genetic variation of COMT (COMT Val158Met) results in lower enzymatic activity and higher dopamine availability in Met carriers. Given the dramatic changes of synaptic dopamine during adolescence, it has been suggested that effects of COMT Val158Met genotypes might have oppositional effects in adolescents and adults. The present study aims to identify such oppositional COMT Val158Met effects in adolescents and adults in prefrontal brain networks at rest. Resting state functional connectivity data were collected from cross-sectional and multicenter study sites involving 106 healthy young adults (mean age 24 ± 2.6 years), gender matched to 106 randomly chosen 14-year-olds. We selected the anterior medial prefrontal cortex (amPFC) as seed due to its important role as nexus of the executive control and default mode network. We observed a significant age-dependent reversal of COMT Val158Met effects on resting state functional connectivity between amPFC and ventrolateral as well as dorsolateral prefrontal cortex, and parahippocampal gyrus. Val homozygous adults exhibited increased and adolescents decreased connectivity compared to Met homozygotes for all reported regions. Network analyses underscored the importance of the parahippocampal gyrus as mediator of observed effects. Results of this study demonstrate that adolescent and adult resting state networks are dose-dependently and diametrically affected by COMT genotypes following a hypothetical model of dopamine function that follows an inverted U-shaped curve. This study might provide cues for the understanding of disease onset or dopaminergic treatment mechanisms in major neuropsychiatric disorders such as schizophrenia and attention deficit hyperactivity disorder.
DOI:doi:10.1007/s00429-014-0895-5
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1007/s00429-014-0895-5
 Volltext: https://doi.org/10.1007/s00429-014-0895-5
 DOI: https://doi.org/10.1007/s00429-014-0895-5
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Adolescents
 Catechol-O-methyltransferase
 Cognition
 Dopamine
 Functional neuroimaging
 Magnetic resonance imaging
K10plus-PPN:1586296728
Verknüpfungen:→ Zeitschrift

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