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Verfasst von:Schulze, Lars [VerfasserIn]   i
 Schmahl, Christian [VerfasserIn]   i
 Niedtfeld, Inga [VerfasserIn]   i
Titel:Neural correlates of disturbed emotion processing in borderline personality disorder
Titelzusatz:a multimodal meta-analysis
Verf.angabe:Lars Schulze, Christian Schmahl, Inga Niedtfeld
E-Jahr:2016
Jahr:January 15, 2016
Umfang:10 S.
Fussnoten:Gesehen am 18.01.2019
Titel Quelle:Enthalten in: Biological psychiatry
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1985
Jahr Quelle:2016
Band/Heft Quelle:79(2016), 2, Seite 97-106
ISSN Quelle:1873-2402
Abstract:Background: Disturbances in the processing and regulation of emotions are core symptoms of borderline personality disorder (BPD). To further elucidate neural underpinnings of BPD, the present meta-analysis summarizes functional neuroimaging findings of emotion processing tasks, as well as structural neuroimaging findings, and investigates multimodally affected brain regions. Methods: Combined coordinate- and image-based meta-analyses were calculated using anisotropic effect size signed differential mapping. Nineteen functional neuroimaging studies investigating the processing of negative compared with neutral stimuli in a total of 281 patients with BPD and 293 healthy control subjects (HC) were included. In addition, 10 studies investigating gray matter abnormalities in 263 patients with BPD and 278 HC were analyzed. Results: Compared with HC, BPD patients showed relatively increased activation of the left amygdala and posterior cingulate cortex, along with blunted responses of the bilateral dorsolateral prefrontal cortex, during the processing of negative emotional stimuli. The multimodal analysis identified the left amygdala to be characterized by a combination of functional hyperactivity and smaller gray matter volume compared with HC. Hyperresponsivity of the amygdala was moderated by medication status of the patient samples. Medication-free samples were characterized by limbic hyperactivity, whereas no such group differences were found in patients currently taking psychotropic medication. Conclusions: Results strengthen the assumption that dysfunctional dorsolateral prefrontal and limbic brain regions are a hallmark feature of BPD and therefore are consistent with the conceptualization of BPD as an emotion dysregulation disorder.
DOI:doi:10.1016/j.biopsych.2015.03.027
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1016/j.biopsych.2015.03.027
 Volltext: http://www.sciencedirect.com/science/article/pii/S0006322315002784
 DOI: https://doi.org/10.1016/j.biopsych.2015.03.027
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Emotion
 Borderline personality disorder
 Functional magnetic resonance imaging
 Meta-analysis
 Signed differential mapping
 Voxel-based morphometry
K10plus-PPN:1586388959
Verknüpfungen:→ Zeitschrift

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