Thymuskarzinome

• Verfasst von: Ströbel, Philipp [VerfasserIn]
• Verfasst von: Weis, Cleo-Aron Thias [VerfasserIn]
• Verfasst von: Marx, Alexander [VerfasserIn]
• Titel: Thymuskarzinome
• Paralleltitel: Thymic carcinomas
• Verf.angabe: P. Ströbel, C.-A. Weis, A. Marx
• E-Jahr: 2016
• Jahr: 18. August 2016
• Umfang: 9 S.
• Fussnoten: Gesehen am 21.01.2019
• Titel Quelle: Enthalten in: Der Pathologe
• Ort Quelle: Berlin : Springer, 1994
• Jahr Quelle: 2016
• Band/Heft Quelle: 37(2016), 5, Seite 425-433
• ISSN Quelle: 1432-1963
• DOI: doi:10.1007/s00292-016-0194-4
• Datenträger: Online-Ressource
• Sprache: ger
• Sach-SW: Differential diagnosis
• Sach-SW: Differenzialdiagnose
• Sach-SW: Immunhistochemie
• Sach-SW: Immunohistochemistry
• Sach-SW: Oncological strategies
• Sach-SW: Onkologische Strategien
• Sach-SW: Thymom
• Sach-SW: Thymoma
• Sach-SW: WHO classification
• Sach-SW: WHO-Klassifikation
• K10plus-PPN: 1586435604

Abstract

Thymic carcinomas (TC) are approximately 10 times less prevalent than thymomas but of high clinical relevance because they are more aggressive, less frequently resectable than thymomas and usually refractory to classical and targeted long-term treatment approaches. Furthermore, in children and adolescents TC are more frequent than thymomas and particularly in this age group, germ cell tumors need to be a differential diagnostic consideration. In diagnostic terms pathologists face two challenges: a), the distinction between thymic carcinomas and thymomas with a similar appearance and b), the distinction between TC and histologically similar metastases and tumor extensions from other primary tumors. Overcoming these diagnostic challenges is the focus of the new WHO classification of thymic epithelial tumors. The objectives of this review are to highlight novel aspects of the WHO classification of thymic carcinomas and to address therapeutically relevant diagnostic pitfalls.