Technology, applications, and process challenges of dual chamber systems

• Verfasst von: Werk, Tobias [VerfasserIn]
• Verfasst von: Hafner, Mathias [VerfasserIn]
• Titel: Technology, applications, and process challenges of dual chamber systems
• Verf.angabe: Tobias Werk, Imke S. Ludwig, Joerg Luemkemann, Hanns-Christian Mahler, Joerg Huwyler, Mathias Hafner
• E-Jahr: 2016
• Jahr: January 2016
• Umfang: 6 S.
• Fussnoten: Gesehen am 23.01.2019
• Titel Quelle: Enthalten in: Journal of pharmaceutical sciences
• Ort Quelle: Amsterdam : Elsevier, 1911
• Jahr Quelle: 2016
• Band/Heft Quelle: 105(2016), 1, Seite 4-9
• ISSN Quelle: 1520-6017
• DOI: doi:10.1016/j.xphs.2015.11.025
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: aseptic processing
• Sach-SW: biologics
• Sach-SW: biopharmaceutical
• Sach-SW: dual-chamber cartridge
• Sach-SW: dual-chamber syringe
• Sach-SW: dual-chamber systems
• Sach-SW: fixed dose combination
• Sach-SW: freeze-drying
• Sach-SW: home care
• Sach-SW: small volume parenterals
• K10plus-PPN: 1586499181

Abstract

Dual-chamber systems provide an option as a drug and device combination product, when home care and emergency lyophilized products are intended. Nevertheless, until today, there are only a few products on the market, due to the challenges and limitations in manufacturability, product formulation, and product stability in a dual-chamber configuration, as well as economic considerations. This review serves to describe currently available dual-chamber systems and to discuss factors to be considered for appropriate selection and establishing fill-finish processes.