Status: Bibliographieeintrag
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| Verfasst von: | Birk, Richard [VerfasserIn]  |
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| | Aderhold, Marc Christoph [VerfasserIn] |
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| | Hörmann, Karl [VerfasserIn] |
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| | Schell, Angela [VerfasserIn] |
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| | Kramer, Benedikt [VerfasserIn] |
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| | Eschenhagen, Till [VerfasserIn] |
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| | Sommer, Ulrich [VerfasserIn] |
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| Titel: | CpG-oligodeoxynucleotides in chronic rhinosinusitis cell culture |
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| Verf.angabe: | Richard Birk, Christoph Aderhold, Karl Hörmann, Angela Wenzel, Benedikt Kramer, Till Eschenhagen and J. Ulrich Sommer |
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| E-Jahr: | 2016 |
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| Jahr: | January-February 2016 |
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| Umfang: | 6 S. |
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| Fussnoten: | Gesehen am 23.01.2019 |
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| Titel Quelle: | Enthalten in: In vivo |
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| Ort Quelle: | Kapandriti, Attiki : IIAR, 2004 |
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| Jahr Quelle: | 2016 |
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| Band/Heft Quelle: | 30(2016), 1, Seite 47-52 |
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| ISSN Quelle: | 1791-7549 |
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| Abstract: | In chronic rhinosinusitis (CRS) an important feature is the infiltration of eosinophils, triggered by T-helper type 2 cells (TH2). Binding of the CpG oligodeoxynucleotide (CpG-ODN) ligand to toll-like receptor 9 (TLR9) induces a shift from a TH2- to a TH1-type response. We evaluated the hypothesis that CpG-ODN could reduce the predominantly TH2-driven response in our cultures. Materials and Methods: Twenty samples from CRS patients with (CRSwNP) and without nasal polyposis (CRSsNP) were cultivated. The expression of interleukin 5 (IL-5), eotaxin 3 and matrix metalloprotease 9 (MMP-9) were evaluated with and without CpG-ODN. Results: Addition of CpG did not influence the expression of IL-5 and eotaxin-3 DNA. Elevated MMP-9 expression in cultures from CRSwNP and CRSsNP patients could be established. Conclusion: CpG does not reduce the attraction of eosinophils since no reduced IL-5 expression was measured in our cultures. Yet, MMP-9 - an important factor in tissue remodelling - was elevated in cultures from CRS patients. |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://iv.iiarjournals.org/content/30/1/47 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Chronic rhinosinusitis |
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| | CpG-ODN |
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| | eotaxin 3 |
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| | IL-5 |
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| | MMP-9 |
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| K10plus-PPN: | 1586516515 |
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| Verknüpfungen: | → Zeitschrift |
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CpG-oligodeoxynucleotides in chronic rhinosinusitis cell culture / Birk, Richard [VerfasserIn]; January-February 2016 (Online-Ressource)
68350993
