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Verfasst von:Heitzmann, Dirk [VerfasserIn]   i
Titel:The in vivo respiratory phenotype of the adenosine A1 receptor knockout mouse
Verf.angabe:Dirk Heitzmann, Philipp Buehler, Frank Schweda, Michael Georgieff, Richard Warth, Joerg Thomas
Jahr:2016
Jahr des Originals:2015
Umfang:13 S.
Fussnoten:Gesehen am 29.01.2019 ; Available online 28 November 2015 ; Im Titel ist "1" tiefgestellt
Titel Quelle:Enthalten in: Respiratory physiology & neurobiology
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 2002
Jahr Quelle:2016
Band/Heft Quelle:222(2016), Seite 16-28
ISSN Quelle:1878-1519
Abstract:The nucleoside adenosine has been implicated in the regulation of respiration, especially during hypoxia in the newborn. In this study the role of adenosine A1 receptors for the control of respiration was investigated in vivo. To this end, respiration of unrestrained adult and neonatal adenosine A1 receptor knockout mice (A1R-/- ) was measured in a plethysmographic device. Under control conditions (21% O2) and mild hypoxia (12-15% O2) no difference of respiratory parameters was observed between adult wildtype (A1R+/+) and A1R-/- mice. Under more severe hypoxia (6-10% O2) A1R+/+ mice showed, after a transient increase of respiration, a decrease of respiration frequency (fR) and tidal volume (VT) leading to a decrease of minute volume (MV). This depression of respiration during severe hypoxia was absent in A1R-/- mice which displayed a stimulated respiration as indicated by the enhancement of MV by some 50-60%. During hypercapnia-hyperoxia (3-10% CO2/97-90 % O2), no obvious differences in respiration of A1R-/- and A1R+/+ was observed. In neonatal mice, the respiratory response to hypoxia was surprisingly similar in both genotypes. However, neonatal A1R-/- mice appeared to have more frequently periods of apnea during hypoxia and in the post-hypoxic control period. In conclusion, these data indicate that the adenosine A1 receptor is an important molecular component mediating hypoxic depression in adult mice and it appears to stabilize respiration of neonatal mice.
DOI:doi:10.1016/j.resp.2015.11.005
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1016/j.resp.2015.11.005
 Volltext: http://www.sciencedirect.com/science/article/pii/S156990481530077X
 DOI: https://doi.org/10.1016/j.resp.2015.11.005
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:A receptor knockout
 Adenosine
 HRD
 Hypoxia
 Mouse
K10plus-PPN:1586668676
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