Co-assembly of chitosan and phospholipids into hybrid hydrogels

• Verfasst von: Mendes, Ana Carina Loureiro [VerfasserIn]
• Verfasst von: Gorzelanny, Christian [VerfasserIn]
• Titel: Co-assembly of chitosan and phospholipids into hybrid hydrogels
• Verf.angabe: Ana C. Mendes, Elhamalsadat Shekarforoush, Christoph Engwer, Sophie R. Beeren, Christian Gorzelanny, Francisco M. Goycoolea and Ioannis S. Chronakis
• E-Jahr: 2016
• Jahr: 02.11.2016
• Umfang: 12 S.
• Fussnoten: Gesehen am 04.02.2019
• Titel Quelle: Enthalten in: Pure and applied chemistry
• Ort Quelle: Berlin : de Gruyter, 1960
• Jahr Quelle: 2016
• Band/Heft Quelle: 88(2016), 9, Seite 905-916
• ISSN Quelle: 1365-3075
• DOI: doi:10.1515/pac-2016-0708
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: biomaterials
• Sach-SW: carbohydrates
• Sach-SW: chitosan
• Sach-SW: colloids
• Sach-SW: EUCHIS-12
• Sach-SW: hydrogel
• Sach-SW: ICCC-13
• Sach-SW: phospholipids
• Sach-SW: self-assembly
• K10plus-PPN: 1587211955

Abstract

Novel hybrid hydrogels were formed by adding chitosan (Ch) to phospholipids (P) self-assembled particles in lactic acid. The effect of the phospholipid concentration on the hydrogel properties was investigated and was observed to affect the rate of hydrogel formation and viscoelastic properties. A lower concentration of phospholipids (0.5% wt/v) in the mixture, facilitates faster network formation as observed by Dynamic Light Scattering, with lower elastic modulus than the hydrogels formed with higher phospholipid content. The nano-porous structure of Ch/P hydrogels, with a diameter of 260±20 nm, as observed by cryo-scanning electron microscopy, facilitated the penetration of water and swelling. Cell studies revealed suitable biocompatibility of the Ch/P hydrogels that can be used within life sciences applications.