Nonsurgical therapies for resected and unresected pancreatic cancer in Europe and USA in 2003-2014

• Verfasst von: Huang, Lei [VerfasserIn]
• Verfasst von: Balavarca, Yesilda [VerfasserIn]
• Verfasst von: Schrotz-King, Petra [VerfasserIn]
• Verfasst von: Brenner, Hermann [VerfasserIn]
• Titel: Nonsurgical therapies for resected and unresected pancreatic cancer in Europe and USA in 2003-2014
• Titelzusatz: a large international population-based study
• Verf.angabe: Lei Huang, Lina Jansen, Yesilda Balavarca, Lydia van der Geest, Valery Lemmens, Liesbet Van Eycken, Harlinde De Schutter, Tom B. Johannesen, Maja Primic‐Žakelj, Vesna Zadnik, Margit Mägi, Dianne Pulte, Petra Schrotz‐King and Hermann Brenner
• E-Jahr: 2018
• Jahr: 20 Jun 2018
• Umfang: 13 S.
• Fussnoten: Gesehen am 04.02.2019
• Titel Quelle: Enthalten in: International journal of cancer
• Ort Quelle: Bognor Regis : Wiley-Liss, 1966
• Jahr Quelle: 2018
• Band/Heft Quelle: 143(2018), 12, Seite 3227-3239
• ISSN Quelle: 1097-0215
• DOI: doi:10.1002/ijc.31628
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Europe
• Sach-SW: nonsurgical therapies
• Sach-SW: pancreatic cancer
• Sach-SW: population-based
• Sach-SW: USA
• K10plus-PPN: 1587214350

Abstract

The role of chemotherapy in the treatment of pancreatic cancer (PaC) has been well-established, while radiation plays ambiguous roles. This international large-scale population-based study aimed to investigate the real-world application of chemotherapy and radiotherapy for resected and unresected PaC in Europe and USA. Population-based data from multiple European national cancer registries and the US Surveillance, Epidemiology and End Results (SEER)-18 database during 2003-2014 were analyzed. Temporal trends and geographical variations in the application rates of chemotherapy and radiotherapy were quantified using age standardization. Associations of treatment with demographic and clinical characteristics were assessed using multivariable logistic regression. A total of 141,533 PaC patients were analyzed. From 2003-2005 to 2012-2014, chemotherapy administration rates increased in most countries and more strongly among resected patients, while radiation rates were generally low with a slight decline or no obvious trend. In 2012-2014, 12.5% (Estonia) to 61.7% (Belgium) of resected and 17.1% (Slovenia) to 56.9% (Belgium) of unresected patients received chemotherapy. Radiation was administered in 2.6% (Netherlands) to 32.6% (USA) of resected and 1.0% (USA) to 6.0% (Belgium) of unresected patients. Strong temporal and geographical variations were observed. Patterns and strengths of associations of treatment administration with various demographic and clinical factors differed substantially between resected and unresected cancers and varied greatly across countries. Conclusively, administration of chemotherapy but not radiotherapy for PaC increased during the last decade in Europe and USA. Treatment rates were low and the uptake strongly varied across countries, highlighting the need for standardization in PaC treatment to improve patient care.