Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Ohno-Matsui, Kyoko [VerfasserIn]   i
 Jonas, Jost B. [VerfasserIn]   i
 Spaide, Richard F. [VerfasserIn]   i
Titel:Macular Bruch membrane holes in choroidal neovascularization-related myopic macular atrophy by swept-source optical coherence tomography
Verf.angabe:Kyoko Ohno-Matsui, Jost B. Jonas, and Richard F. Spaide
E-Jahr:2016
Jahr:February 2016
Umfang:7 S.
Fussnoten:Gesehen am 04.02.2019
Titel Quelle:Enthalten in: American journal of ophthalmology
Ort Quelle:New York, NY : Elsevier Science, 1918
Jahr Quelle:2016
Band/Heft Quelle:162(2016), Seite 133-139
ISSN Quelle:1879-1891
Abstract:Purpose: To determine frequency and associations of macular Bruch membrane defects in the region of macular atrophy developing after the onset of myopic choroidal neovascularization (CNV). Design: Retrospective observational case series. Methods: The study included all patients who were consecutively examined for high myopia (axial length ≥26.5mm) and CNV-related macular atrophy in the study period from June to July 2015. The patients underwent a comprehensive ophthalmologic examination including swept-source optical coherence tomography (OCT) of the macula. Main outcome measures were macular Bruch membrane defects. Results: Out of 33 eyes (28 patients) with myopic CNV-related macular atrophy, 25 eyes (76%) showed macular Bruch membrane defects, which were characterized by a lack of Bruch membrane, retinal pigment epithelium, photoreceptors, and choriocapillaris. At the edges of the macular Bruch membrane defects, the ends of the Bruch membrane were upturned, and an inward protrusion of large choroidal vessels could be detected. In the center of macular Bruch membrane defects, remnants of Bruch membrane could be crumpled. In multivariate analysis, higher prevalence of secondary macular Bruch membrane defects was significantly associated with a lower prevalence of intravitreal medical therapy (P < .001) after adjusting for larger macular atrophy area size (P < .001) and longer interval between development of the CNV and final examination (P = .42). Conclusions: Macular Bruch membrane defects belong to the hallmarks of myopic CNV-related macular atrophy. Since macular Bruch membrane defects lack photoreceptors and thus represent psychophysically an absolute scotoma, they are of profound importance for visual prognosis. As incidentally observed at study end, the prevalence of macular Bruch membrane defects may be lower if a previous myopic CNV was treated by intravitreal medical therapy.
DOI:doi:10.1016/j.ajo.2015.11.014
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1016/j.ajo.2015.11.014
 Volltext: http://www.sciencedirect.com/science/article/pii/S0002939415007023
 DOI: https://doi.org/10.1016/j.ajo.2015.11.014
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1587252546
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68354692   QR-Code
zum Seitenanfang