Quantitative sodium MRI of kidney

• Verfasst von: Zöllner, Frank G. [VerfasserIn]
• Verfasst von: Budjan, Johannes [VerfasserIn]
• Verfasst von: Schönberg, Stefan [VerfasserIn]
• Verfasst von: Schad, Lothar R. [VerfasserIn]
• Verfasst von: Haneder, Stefan [VerfasserIn]
• Titel: Quantitative sodium MRI of kidney
• Verf.angabe: Frank G. Zöllner, Simon Konstandin, Jonathan Lommen, Johannes Budjan, Stefan O. Schoenberg, Lothar R. Schad, Stefan Haneder
• Jahr: 2016
• Jahr des Originals: 2015
• Umfang: 9 S.
• Fussnoten: Gesehen am 11.02.2019 ; Published online in Wiley Online Library: 27 February 2015
• Titel Quelle: Enthalten in: NMR in biomedicine
• Ort Quelle: New York, NY : Wiley, 1988
• Jahr Quelle: 2016
• Band/Heft Quelle: 29(2016), 2, Seite 197-205
• ISSN Quelle: 1099-1492
• DOI: doi:10.1002/nbm.3274
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: sodium MRI
• Sach-SW: clinical
• Sach-SW: kidney
• Sach-SW: pre-clinical
• Sach-SW: review
• K10plus-PPN: 1587458004

Abstract

One of the main tasks of the human kidneys is to maintain the homeostasis of the body's fluid and electrolyte balance by filtration of the plasma and excretion of the end products. Herein, the regulation of extracellular sodium in the kidney is of particular importance. Sodium MRI (23Na MRI) allows for the absolute quantification of the tissue sodium concentration (TSC) and thereby provides a direct link between TSC and tissue viability. Renal 23Na MRI can provide new insights into physiological tissue function and viability thought to differ from the information obtained by standard 1H MRI. Sodium imaging has the potential to become an independent surrogate biomarker not only for renal imaging, but also for oncology indications. However, this technique is now on the threshold of clinical implementation. Numerous, initial pre-clinical and clinical studies have already outlined the potential of this technique; however, future studies need to be extended to larger patient groups to show the diagnostic outcome. In conclusion, 23Na MRI is seen as a powerful technique with the option to establish a non-invasive renal biomarker for tissue viability, but is still a long way from real clinical implementation.