Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Kayser, Sabine [VerfasserIn]   i
 Stadtherr, Peter [VerfasserIn]   i
 Uppenkamp, Michael [VerfasserIn]   i
 Bochtler, Tilmann [VerfasserIn]   i
 Hegenbart, Ute [VerfasserIn]   i
 Ho, Anthony Dick [VerfasserIn]   i
 Dreger, Peter [VerfasserIn]   i
 Krämer, Alwin [VerfasserIn]   i
Titel:Pretransplant NPM1 MRD levels predict outcome after allogeneic hematopoietic stem cell transplantation in patients with acute myeloid leukemia
Verf.angabe:S. Kayser, A. Benner, C. Thiede, U. Martens, J. Huber, P. Stadtherr, J.W.G. Janssen, C. Röllig, M.J. Uppenkamp, T. Bochtler, U. Hegenbart, G. Ehninger, A.D. Ho, P. Dreger and A. Krämer
E-Jahr:2016
Jahr:29 July 2016
Umfang:7 S.
Fussnoten:Gesehen am 11.02.2019 ; Im Titel ist "NPM1" kursiv geschrieben
Titel Quelle:Enthalten in: Blood cancer journal
Ort Quelle:London [u.a.] : Nature Publishing Group, 2011
Jahr Quelle:2016
Band/Heft Quelle:6(2016) Artikel-Nummer e449, 7 Seiten
ISSN Quelle:2044-5385
Abstract:The objective was to evaluate the prognostic impact of pre-transplant minimal residual disease (MRD) as determined by real-time quantitative polymerase chain reaction in 67 adult NPM1-mutated acute myeloid leukemia patients receiving allogeneic hematopoietic stem cell transplantation (HSCT). Twenty-eight of the 67 patients had a FLT3-ITD (42%). Median age at transplantation was 54.7 years, median follow-up for survival from time of allografting was 4.9 years. At transplantation, 31 patients were in first, 20 in second complete remission (CR) and 16 had refractory disease (RD). Pre-transplant NPM1 MRD levels were measured in 39 CR patients. Overall survival (OS) for patients transplanted in CR was significantly longer as compared to patients with RD (P=0.004), irrespective of whether the patients were transplanted in first or second CR (P=0.74). There was a highly significant difference in OS after allogeneic HSCT between pre-transplant MRD-positive and MRD-negative patients (estimated 5-year OS rates of 40 vs 89%; P=0.007). Multivariable analyses on time to relapse and OS revealed pre-transplant NPM1 MRD levels >1% as an independent prognostic factor for poor survival after allogeneic HSCT, whereas FLT3-ITD had no impact. Notably, outcome of patients with pre-transplant NPM1 MRD positivity >1% was as poor as that of patients transplanted with RD.
DOI:doi:10.1038/bcj.2016.46
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: http://dx.doi.org/10.1038/bcj.2016.46
 Volltext: https://www.nature.com/articles/bcj201646
 DOI: https://doi.org/10.1038/bcj.2016.46
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1587552213
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68356926   QR-Code
zum Seitenanfang