Status: Bibliographieeintrag
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| Verfasst von: | Scholz, Beate [VerfasserIn]  |
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| | Wojtarowicz, Jessica [VerfasserIn] |
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| | Mogler, Carolin [VerfasserIn] |
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| | Boutros, Michael [VerfasserIn] |
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| | Augustin, Hellmut [VerfasserIn] |
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| Titel: | Endothelial RSPO3 controls vascular stability and pruning through non-canonical WNT/Ca2+/NFAT signaling |
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| Verf.angabe: | Beate Scholz, Claudia Korn, Jessica Wojtarowicz, Carolin Mogler, Iris Augustin, Michael Boutros, Christof Niehrs, and Hellmut G. Augustin |
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| E-Jahr: | 2016 |
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| Jahr: | January 11, 2016 |
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| Umfang: | 15 S. |
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| Fussnoten: | Gesehen am 12.02.2019 |
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| Titel Quelle: | Enthalten in: Developmental cell |
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| Ort Quelle: | Cambridge, Mass. : Cell Press, 2001 |
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| Jahr Quelle: | 2016 |
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| Band/Heft Quelle: | 36(2016), 1, Seite 79-93 |
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| ISSN Quelle: | 1878-1551 |
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| Abstract: | The WNT signaling enhancer R-spondin3 (RSPO3) is prominently expressed in the vasculature. Correspondingly, embryonic lethality of Rspo3-deficient mice is caused by vessel remodeling defects. Yet the mechanisms underlying vascular RSPO3 function remain elusive. Inducible endothelial Rspo3 deletion (Rspo3-iECKO) resulted in perturbed developmental and tumor vascular remodeling. Endothelial cell apoptosis and vascular pruning led to reduced microvessel density in Rspo3-iECKO mice. Rspo3-iECKO mice strikingly phenocopied the non-canonical WNT signaling-induced vascular defects of mice deleted for the WNT secretion factor Evi/Wls. An endothelial screen for RSPO3 and EVI/WLS co-regulated genes identified Rnf213, Usp18, and Trim30α. RNF213 targets filamin A and NFAT1 for proteasomal degradation attenuating non-canonical WNT/Ca2+ signaling. Likewise, USP18 and TRIM5α inhibited NFAT1 activation. Consequently, NFAT protein levels were decreased in endothelial cells of Rspo3-iECKO mice and pharmacological NFAT inhibition phenocopied Rspo3-iECKO mice. The data identify endothelial RSPO3-driven non-canonical WNT/Ca2+/NFAT signaling as a critical maintenance pathway of the remodeling vasculature. |
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| DOI: | doi:10.1016/j.devcel.2015.12.015 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://dx.doi.org/10.1016/j.devcel.2015.12.015 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S153458071500800X |
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| | DOI: https://doi.org/10.1016/j.devcel.2015.12.015 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | angiogenesis |
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| | Moyamoya |
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| | NFAT |
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| | non-canonical WNT pathway |
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| | R-spondin |
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| | RNF213 |
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| | RSPO3 |
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| | vascular pruning |
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| | vascular regression |
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| | vascular remodeling |
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| | WNT |
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| K10plus-PPN: | 1587594331 |
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| Verknüpfungen: | → Zeitschrift |
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Endothelial RSPO3 controls vascular stability and pruning through non-canonical WNT/Ca2+/NFAT signaling / Scholz, Beate [VerfasserIn]; January 11, 2016 (Online-Ressource)
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