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Verfasst von:Palma-Gudiel, Helena [VerfasserIn]   i
 Deuschle, Michael [VerfasserIn]   i
Titel:Epigenetics-by-sex interaction for somatization conferred by methylation at the promoter region of SLC6A4 gene
Verf.angabe:H. Palma-Gudiel, V. Peralta, M. Deuschle, V. Navarro, L. Fañanás
Jahr:2019
Jahr des Originals:2018
Umfang:7 S.
Fussnoten:Available online 08 September 2018 ; Gesehen am 13.02.2019
Titel Quelle:Enthalten in: Progress in neuro-psychopharmacology & biological psychiatry
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1982
Jahr Quelle:2019
Band/Heft Quelle:89(2019), Seite 125-131
ISSN Quelle:1878-4216
Abstract:Background Depression, anxiety and somatoform disorders are all more prevalent in women than in men. However, specific biological mechanisms contributing to such sex differences remain unknown. Serotonergic pathways are involved in mood and behavior regulation and thus have been suggested to be altered in several psychiatric disorders. The serotonin transporter (SERT), encoded by SLC6A4 gene, has received major attention due to its crucial role in serotonergic transmission. Methods 148 monozygotic twin subjects were assessed for (i) lifetime categorical diagnosis of anxious-depressive disorders, following SCID-I-based DSM-IV criteria, and (ii) current psychiatric symptomatology, from a dimensional approach, by means of the Brief Symptom Inventory (BSI). SLC6A4 gene methylation was analyzed by means of Infinium HumanMethylation450 in a subset of the sample. CpG-specific methylation at the promoter region of SLC6A4 gene was further analyzed by means of pyrosequencing technology in the total sample. Results SLC6A4 methylation was found to be significantly higher in women when compared to men independent of DSM-IV diagnosis. SLC6A4 methylation was further associated with the BSI-derived somatization dimension. Conclusions Female hypermethylation of a discrete region located within SLC6A4 promoter region could underlie differential SERT expression in women when compared to men and could be one of the causative mechanisms by which women exhibit increased prevalence of somatic symptoms.
DOI:doi:10.1016/j.pnpbp.2018.09.002
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1016/j.pnpbp.2018.09.002
 Volltext: http://www.sciencedirect.com/science/article/pii/S0278584618305001
 DOI: https://doi.org/10.1016/j.pnpbp.2018.09.002
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:DNA methylation
 Serotonin transporter
 Sex differences
 Somatization symptoms
K10plus-PPN:1587632896
Verknüpfungen:→ Zeitschrift

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