Insulin-like growth factor system in neuroblastoma tumorigenesis and apoptosis

• Verfasst von: Zumkeller, Walter [VerfasserIn]
• Verfasst von: Schwab, Manfred [VerfasserIn]
• Titel: Insulin-like growth factor system in neuroblastoma tumorigenesis and apoptosis
• Titelzusatz: potential diagnostic and therapeutic perspectives
• Verf.angabe: W. Zumkeller, M. Schwab
• Jahr: 1999
• Umfang: 4 S.
• Fussnoten: Elektronische Reproduktion der Druckausgabe ; Gesehen am 15.02.2019
• Titel Quelle: Enthalten in: Hormone and metabolic research
• Ort Quelle: Stuttgart [u.a.] : Thieme, 1969
• Jahr Quelle: 1999
• Band/Heft Quelle: 31(1999), 2/3, Seite 138-141
• ISSN Quelle: 1439-4286
• DOI: doi:10.1055/s-2007-978711
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1587713543

Abstract

Apoptosis is a cell death program which is modulated by a variety of factors including growth factors, signal transduction molecules and inducers of gene expression or DNA replication. Of particular interest is Type I insulin-like growth factor receptor which contains a tyrosine kinase domain linked to the ras-raf-MAPK cascade. This receptor has antiapoptotic effects in a number of in vivo and in vitro models, thus making IGF-I-R a potential target for gene therapy. Particularly the growth of neuroblastoma depends on IGFs which exert their effect through the Type I IGF receptor. This review highlights the role of the IGF-system in neuroblastoma and points at possible modulators with the aim of inducing differentiation or apoptosis of tumor cells.