The glucocorticoid receptor is required for stress erythropoiesis

• Verfasst von: Bauer, Anton [VerfasserIn]
• Verfasst von: Tronche, François [VerfasserIn]
• Verfasst von: Kellendonk, Christoph [VerfasserIn]
• Verfasst von: Reichardt, Holger Michael [VerfasserIn]
• Verfasst von: Schütz, Günther [VerfasserIn]
• Titel: The glucocorticoid receptor is required for stress erythropoiesis
• Verf.angabe: Anton Bauer, Francois Tronche, Oliver Wessely, Christoph Kellendonk, Holger M. Reichardt, Peter Steinlein, Günther Schütz, and Hartmut Beug
• Jahr: 1999
• Umfang: 7 S.
• Fussnoten: Gesehen am 18.02.2019
• Titel Quelle: Enthalten in: Genes & development
• Ort Quelle: Stanford, Calif. : HighWire Press, 1987
• Jahr Quelle: 1999
• Band/Heft Quelle: 13(1999), Seite 2996-3002
• ISSN Quelle: 1549-5477
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1587733382

Abstract

The glucocorticoid receptor (GR) coordinates a multitude of physiological responses in vivo. In vitro, glucocorticoids are required for sustained proliferation of erythroid progenitors (ebls). Here, we analyze the impact of the GR on erythropoiesis in vivo, using GR-deficient mice or mice expressing a GR defective for transactivation. In vitro, sustained proliferation of primary ebls requires an intact GR. In vivo, the GR is required for rapid expansion of ebls under stress situations like erythrolysis or hypoxia. A particular, GR-sensitive progenitor could be identified as being responsible for the stress response. Thus, GR-mediated regulation of ebl proliferation is essential for stress erythropoiesis in vivo.