Clinical prognostic variables in young patients (under 40 years) with hepatitis B virus-associated hepatocellular carcinoma

• Verfasst von: Wang, Qin [VerfasserIn]
• Verfasst von: Rahbari, Nuh Nabi [VerfasserIn]
• Titel: Clinical prognostic variables in young patients (under 40 years) with hepatitis B virus-associated hepatocellular carcinoma
• Verf.angabe: Qin Wang, Wei Luan, Gerald A. Villanueva, Nuh N. Rahbari, Herman T. Yee, Fotini Manizate, Spiros P. Hiotis
• E-Jahr: 2012
• Jahr: 09 January 2012
• Umfang: 5 S.
• Fussnoten: Gesehen am 20.02.2019
• Titel Quelle: Enthalten in: Journal of digestive diseases
• Ort Quelle: Oxford [u.a.] : Wiley-Blackwell, 2007
• Jahr Quelle: 2012
• Band/Heft Quelle: 13(2012), 4, Seite 214-218
• ISSN Quelle: 1751-2980
• DOI: doi:10.1111/j.1751-2980.2012.00577.x
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: hepatitis B
• Sach-SW: hepatocellular carcinoma
• Sach-SW: viral hepatitis
• K10plus-PPN: 1587832305

Abstract

OBJECTIVE: The aim of this study was to determine the impact of hepatocelluar carcinoma (HCC) screening in chronic hepatitis B patients who did not meet the current screening recommendations. METHODS: Patients who were admitted to Bellevue Hospital Center with HCC were assessed for risk factors, cirrhosis and tumor-specific factors. Eligibility for liver transplantation or resection with favorable outcome was determined by applying Milan criteria. RESULTS: In all 93 patients were diagnosed with hepatitis B virus (HBV)-associated HCC, 18 of whom were under 40 years. Cirrhosis was infrequently associated with HCC in this group, with most cancers occurring in non-cirrhotic patients (12/18, 66.7%). No patient developed HCC outside the American Association for the Study of Liver Diseases (AASLD) cancer screening recommendations (young age, non-cirrhotic) were eligible for liver transplantation or resection with favorable outcomes (within Milan criteria). However, HCC patients who were diagnosed within AASLD screening recommendations did meet Milan criteria in 17.3% (14/81) patients. CONCLUSIONS: Current guidelines for HCC screening in patients with HBV may lead to a delay in diagnosis in non-cirrhotic patients under 40 years. Consideration should be given to modifying current recommendations to advocate entering HBV patients into a cancer-screening program at young age.