InTAD

• Verfasst von: Okonechnikov, Konstantin [VerfasserIn]
• Verfasst von: Pfister, Stefan [VerfasserIn]
• Titel: InTAD
• Titelzusatz: chromosome conformation guided analysis of enhancer target genes
• Verf.angabe: Konstantin Okonechnikov, Serap Erkek, Jan O. Korbel, Stefan M. Pfister and Lukas Chavez
• Fussnoten: Gesehen am 20.02.2019
• Titel Quelle: Enthalten in: BMC bioinformatics
• Jahr Quelle: 2019
• Band/Heft Quelle: 20(2019) Artikel-Nummer 60, 7 Seiten
• ISSN Quelle: 1471-2105
• DOI: doi:10.1186/s12859-019-2655-2
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1587832372

Abstract

High-throughput technologies for analyzing chromosome conformation at a genome scale have revealed that chromatin is organized in topologically associated domains (TADs). While TADs are relatively stable across cell types, intra-TAD activities are cell type specific. Epigenetic profiling of different tissues and cell-types has identified a large number of non-coding epigenetic regulatory elements (‘enhancers’) that can be located far away from coding genes. Linear proximity is a commonly chosen criterion for associating enhancers with their potential target genes. While enhancers frequently regulate the closest gene, unambiguous identification of enhancer regulated genes remains to be a challenge in the absence of sample matched chromosome conformation data.