Dyslipidemia and eye diseases in the adult Chinese population

• Verfasst von: Wang, Shuang [VerfasserIn]
• Verfasst von: Xu, Liang [VerfasserIn]
• Verfasst von: Jonas, Jost B. [VerfasserIn]
• Titel: Dyslipidemia and eye diseases in the adult Chinese population
• Titelzusatz: the Beijing eye study
• Verf.angabe: Shuang Wang, Liang Xu, Jost B. Jonas, Ya Xing Wang, Qi Sheng You, Hua Yang
• E-Jahr: 2012
• Jahr: March 26, 2012
• Umfang: 6 S.
• Fussnoten: Gesehen am 20.02.2019
• Titel Quelle: Enthalten in: PLOS ONE
• Ort Quelle: San Francisco, California, US : PLOS, 2006
• Jahr Quelle: 2012
• Band/Heft Quelle: 7(2012,3) Artikel-Nummer e26871, 6 Seiten
• ISSN Quelle: 1932-6203
• DOI: doi:10.1371/journal.pone.0026871
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Atrophy
• Sach-SW: Blood pressure
• Sach-SW: Cataracts
• Sach-SW: Cholesterol
• Sach-SW: Diabetic retinopathy
• Sach-SW: Dyslipidemia
• Sach-SW: Glaucoma
• Sach-SW: Intraocular pressure
• K10plus-PPN: 158783510X

Abstract

To determine associations between dyslipidemia and ocular diseases, the population-based Beijing Eye Study 2006 examined 3251 subjects (age≥45 years) who underwent a detailed ophthalmic examination and biochemical blood analysis. Dyslipidemia was defined as any of the following: hypercholesterolemia (total cholesterol concentration≥5.72 mmol/L (220 mg/dL)) or hypertriglyceridemia (triglyceride concentration≥1.70 mmol/L (150 mg/dL)) or low high-density lipoprotein-cholesterol (HDL-C concentration≤0.91 mmol/L (35 mg/dL)). Biochemical blood examinations were available for 2945 (90.6%) subjects. After adjustment for age, gender, habitation region, body mass index, self reported income, blood glucose concentration, diastolic blood pressure and smoking, dyslipidemia was significantly associated with higher intraocular pressure (P<0.001) and beta zone of parapapillary atrophy (P = 0.03). Dyslipidemia was not significantly associated with the prevalence of glaucoma (P = 0.99), retinal vein occlusions (P = 0.92), diabetic retinopathy (P = 0.49), presence of retinal vascular abnormalities such as focal or general arteriolar narrowing, age-related macular degeneration (P = 0.27), nuclear cataract (P = 0.14), cortical cataract (P = 0.93), and subcapsular cataract (P = 0.67). The results make one conclude that, controlled for systemic and socioeconomic parameters, dyslipidemia was not associated with common ophthalmic disorders including glaucoma and age-related macular degeneration.