The bacterial lacZ gene

• Verfasst von: Krüger, Achim [VerfasserIn]
• Verfasst von: Schirrmacher, Volker [VerfasserIn]
• Verfasst von: Khokha, Rama [VerfasserIn]
• Titel: The bacterial lacZ gene
• Titelzusatz: an important tool for metastasis research and evaluation if new cancer therapies
• Verf.angabe: Achim Krüger, Volker Schirrmacher and Rama Khokha
• Umfang: 10 S.
• Fussnoten: Gesehen am 20.02.2019
• Titel Quelle: Enthalten in: Cancer and metastasis reviews
• Jahr Quelle: 1998
• Band/Heft Quelle: 17(1998), 3, S. 285-294
• ISSN Quelle: 1573-7233
• DOI: doi:10.1023/A:1006066706040
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1587840138

Abstract

The bacterial lacZ gene has been used to genetically tag tumor cells. This has been of value, specifically in metastasis research where it allowed to visualize micrometastases and single tumor cells in tissues. lacZ tagging has also provided the feasibility of re-isolating metastatic tumor cell populations for ex vivo molecular analyses. This review summarizes studies that have utilized lacZ tagged tumor cells to understand aspects of metastasis including dormancy, tumor-host interactions, gene modulation and anti-tumor immunity. lacZ tagging is also a valuable tool for evaluating cancer therapies.