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Status: Bibliographieeintrag

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Verfasst von:Sebens, Susanne [VerfasserIn]   i
 Schirrmacher, Volker [VerfasserIn]   i
 Umansky, Viktor [VerfasserIn]   i
Titel:Sialoadhesin-positive host macrophages play an essential role in graft-versus-leukemia reactivity in mice
Verf.angabe:Susanne Müerköster, Marian Rocha, Paul R. Crocker, Volker Schirrmacher, and Victor Umansky
E-Jahr:1999
Jahr:June 15, 1999
Umfang:12 S.
Fussnoten:Gesehen am 20.02.2019 ; Der Vorname von Viktor Umansky ist in der Vorlage mit "c" geschrieben
Titel Quelle:Enthalten in: Blood
Ort Quelle:Washington, DC : American Society of Hematology, 1946
Jahr Quelle:1999
Band/Heft Quelle:93(1999), 12, Seite 4375-4386
ISSN Quelle:1528-0020
Abstract:We recently established an effective immune T-cell-mediated graft-versus-leukemia (GVL) murine model system in which complete tumor remissions were achievable even in advanced metastasized cancer. We now describe that this T-cell-mediated therapy is dependent on host macrophages expressing the lymphocyte adhesion molecule sialoadhesin (Sn). Depletion of Kupffer cells in tumor-bearing mice during adoptive immunotherapy (ADI) or the treatment of these animals with anti-Sn monoclonal antibodies led to complete or partial inhibition of the immune T-cell-mediated therapeutic effect. Furthermore, Sn+ host macrophages in livers formed clusters during ADI with donor CD8 T cells. To test for a possible antigen presentation function of these macrophages, we used as an in vitro model the antigen β-galactosidase for which a dominant major histocompatibility complex (MHC) class I Ld-restricted peptide epitope is known to be recognized by specific CD8 cytotoxic T lymphocytes (CTL). We demonstrate that purified Sn+ macrophages can process exogenous β-galactosidase and stimulate MHC class I peptide-restricted CTL responses. Thus, Sn+ macrophages, which are significantly increased in the liver after ADI, may process tumor-derived proteins via the MHC class I pathway as well as via the MHC class II pathway, as shown previously, and present respective peptide epitopes to CD8 as well as to CD4 immune T cells, respectively. The synergistic interactions observed before between immune CD4 and CD8 T cells during ADI could thus occur in the observed clusters with Sn+ host macrophages.
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Volltext: http://www.bloodjournal.org/content/93/12/4375
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1587840987
Verknüpfungen:→ Zeitschrift

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