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Status: Bibliographieeintrag

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Verfasst von:Knobloch, Martina [VerfasserIn]   i
 Schönrich, Günther [VerfasserIn]   i
 Schenkel, Johannes [VerfasserIn]   i
 Hämmerling, Günter J. [VerfasserIn]   i
 Arnold, Bernd [VerfasserIn]   i
Titel:T cell activation and thymic tolerance induction require different adhesion intensities of the CD8 co-receptor
Verf.angabe:Martina Knobloch, Günther Schönrich, Johannes Schenkel, Marie Malissen, Bernard Malissen, Anne-Marie Schmitt-Verhulst, Günter J. Hämmerling, and Bernd Arnold
Umfang:6 S.
Fussnoten:Gesehen am 21.02.2019
Titel Quelle:Enthalten in: International immunology
Jahr Quelle:1992
Band/Heft Quelle:4(1992), 10, S. 1169-1174
ISSN Quelle:1460-2377
Abstract:Activation of mature lymphocytes requires in addition to the TCR contact with the corresponding antigen the binding of the CD8 or CD4 co-receptors to MHC class I or class II proteins respectively. To investigate the contribution of the CD8 - class I interaction to the elimination of autoreactive T cells during negative selection in the thymus we generated two types of transgenic mice. One set expressed a modified Kb molecule which contained a human HLA-A2 α3 domain, thereby missing the binding residues for the murine CD8 molecules. The second set of mice expressed an anti-Kb specific TCR. Both lines were crossed and in the resulting double transgenic mice the development of Kb-reactlve T cells was followed with an anti-clonotyplc antibody. Surprisingly, efficient clonal deletion In the thymus was still observed, although the reduced CD8 - class l adhesion abrogated effector functions in vivo and in vitro. These results imply that even T cells with intermediate affinity for self are negatively selected In the thymus despite the fact that they are not able to react against self antigens in the periphery. Thus a safety window is created which decreases the risk of autoaggression.
DOI:doi:10.1093/intimm/4.10.1169
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Verlag: http://dx.doi.org/10.1093/intimm/4.10.1169
 Verlag: https://academic.oup.com/intimm/article/4/10/1169/659920
 DOI: https://doi.org/10.1093/intimm/4.10.1169
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1587860325
Verknüpfungen:→ Zeitschrift

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