Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Knobloch, Martina [VerfasserIn]  |
| Schönrich, Günther [VerfasserIn]  |
| Schenkel, Johannes [VerfasserIn]  |
| Hämmerling, Günter J. [VerfasserIn]  |
| Arnold, Bernd [VerfasserIn]  |
Titel: | T cell activation and thymic tolerance induction require different adhesion intensities of the CD8 co-receptor |
Verf.angabe: | Martina Knobloch, Günther Schönrich, Johannes Schenkel, Marie Malissen, Bernard Malissen, Anne-Marie Schmitt-Verhulst, Günter J. Hämmerling, and Bernd Arnold |
Umfang: | 6 S. |
Fussnoten: | Gesehen am 21.02.2019 |
Titel Quelle: | Enthalten in: International immunology |
Jahr Quelle: | 1992 |
Band/Heft Quelle: | 4(1992), 10, S. 1169-1174 |
ISSN Quelle: | 1460-2377 |
Abstract: | Activation of mature lymphocytes requires in addition to the TCR contact with the corresponding antigen the binding of the CD8 or CD4 co-receptors to MHC class I or class II proteins respectively. To investigate the contribution of the CD8 - class I interaction to the elimination of autoreactive T cells during negative selection in the thymus we generated two types of transgenic mice. One set expressed a modified Kb molecule which contained a human HLA-A2 α3 domain, thereby missing the binding residues for the murine CD8 molecules. The second set of mice expressed an anti-Kb specific TCR. Both lines were crossed and in the resulting double transgenic mice the development of Kb-reactlve T cells was followed with an anti-clonotyplc antibody. Surprisingly, efficient clonal deletion In the thymus was still observed, although the reduced CD8 - class l adhesion abrogated effector functions in vivo and in vitro. These results imply that even T cells with intermediate affinity for self are negatively selected In the thymus despite the fact that they are not able to react against self antigens in the periphery. Thus a safety window is created which decreases the risk of autoaggression. |
DOI: | doi:10.1093/intimm/4.10.1169 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Verlag: http://dx.doi.org/10.1093/intimm/4.10.1169 |
| Verlag: https://academic.oup.com/intimm/article/4/10/1169/659920 |
| DOI: https://doi.org/10.1093/intimm/4.10.1169 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1587860325 |
Verknüpfungen: | → Zeitschrift |
T cell activation and thymic tolerance induction require different adhesion intensities of the CD8 co-receptor / Knobloch, Martina [VerfasserIn] (Online-Ressource)
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